Results 121 to 130 of about 1,660,548 (303)

Nonlinear dynamics of self-sustained supersonic reaction waves: Fickett's detonation analogue

open access: yes, 2011
The present study investigates the spatio-temporal variability in the dynamics of self-sustained supersonic reaction waves propagating through an excitable medium.
G. B. Whitham   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Energy Release Rate of Piezoelectric Laminated Cylindrical Shell with Delamination under Circumferential Concentrated Load

open access: yesNonlinear Engineering, 2015
The delamination growth may occur in piezoelectric laminated shell with delamination under a combined electro-thermo-mechanical loading. Based on the piezoelectric theory, the variational principle of moving boundary and considering the contact ...
Jinhua Yang, Wenliang Fan
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Convergence of strain energy release rate components for edge-delaminated composite laminates [PDF]

open access: yes
Strain energy release rates for edge delaminated composite laminates were obtained using quasi 3 dimensional finite element analysis. The problem of edge delamination at the -35/90 interfaces of an 8-ply composite laminate subjected to uniform axial ...
Aminpour, M. A.   +2 more
core   +1 more source

The Effect of Configuration to Interaction Energy Between The Segments of Chitosan and Ascorbic Acid Molecule: Theoretical Study of Drug Release Control [PDF]

open access: yes, 2015
Polymer systems plays an important role in drug delivery, which can control the time release of the drug, reduce the rate of degradation of the drug, and can reduce the toxic properties of the drug.
Hildayani, Suci Zulaikha   +1 more
core  

Tailoring laser-generated plasmas for efficient nuclear excitation by electron capture

open access: yes, 2018
The optimal parameters for nuclear excitation by electron capture in plasma environments generated by the interaction of ultra-strong optical lasers with solid matter are investigated theoretically.
Gunst, Jonas   +3 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy