Results 91 to 100 of about 8,399,207 (351)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Decision-support method for profitable residential energy retrofitting based on energy-related occupant behaviour [PDF]

, 2019
Low-carbon energy retrofitting in buildings plays an important role because 75% of European buildings are considered inefficient and more than 40% are currently over 50 years old.
Barrios Padura, Ángela, Lizana Moral, Francisco Jesús, Molina Huelva, Marta, Serrano Jiménez, Antonio José   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Quantifying Savings and Evaluating Cost Allocation Methods in Energy Communities: A Data-Driven Approach

Energies
Energy Communities (ECs) have emerged as a key instrument for promoting local renewable energy integration and citizen participation in the energy transition.
David González-Asenjo, Luis R. Izquierdo   +1 more
doaj   +1 more source

Quantifying HVAC Energy Savings Through Occupant-Centric Control: A Computational Simulation Approach [PDF]

JES: Journal of Engineering Sciences
Smart systems are a modern technology that positively affects building energy consumption and can significantly reduce the energy cost, especially for office buildings.
Ahmed Elfayoumy
doaj   +1 more source

Saving Water Saves Energy

, 2006
Hot water use in households, for showers and baths as well as for washing clothes and dishes, is a major driver of household energy consumption. Other household uses of water (such as irrigating landscaping) require additional energy in other sectors to transport and treat the water before use, and to treat wastewater.
McMahon, James E., Whitehead, Camilla Dunham, Biermayer, Peter   +2 more
openaire   +1 more source

Renewable energy and energy savings [PDF]

, 2009
Tato práce se zabývá energetickým využitím odpadů. V úvodní části práce je zmíněn současný stav obnovitelných zdrojů v ČR. V hlavní části práce je stav odpadu v ČR, legislativa odpadů ČR, možnosti energetického spalování odpadu ve spalovnách.
Veselský, Josef
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Retrospective Examination of Demand-side Energy-efficiency Policies [PDF]

Energy efficiency policies are a primary avenue for reducing carbon emissions, with potential additional benefits from improved air quality and energy security.
Gillingham, Kenneth, Newell, Richard, Palmer, Karen   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source