Results 71 to 80 of about 3,304,532 (261)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Non-Linear Dynamics Analysis of Protein Sequences. Application to CYP450

open access: yesEntropy, 2019
The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes ...
Xavier F. Cadet   +3 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

MSGM-Net: multi-scale general-modal network for disease and organ segmentation

open access: yesComplex & Intelligent Systems
General and effective medical image segmentation methods achieve pixel-level accurate segmentation of lesions or organs. Existing 2-D networks have demonstrated their effectiveness on single-modal segmentation tasks, but difficult to exploit ...
Dayu Tan   +5 more
doaj   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

FPGA Realization of the Observer-Based Sliding Discrete Fourier Transform

open access: yesIEEE Access, 2022
Discrete Fourier transform (DFT) is a widely used method of signal analysis in digital signal processing. The DFT converts a signal from time domain to frequency domain for further processing.
Peter Plesznik   +2 more
doaj   +1 more source

Recent Advances in Joint Wireless Energy and Information Transfer

open access: yes, 2014
In this paper, we provide an overview of the recent advances in microwave-enabled wireless energy transfer (WET) technologies and their applications in wireless communications. Specifically, we divide our discussions into three parts. First, we introduce
Bi, Suzhi, Ho, Chin Keong, Zhang, Rui
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Plancherel theorem and quaternion Fourier transform for square integrable functions

open access: yes, 2018
The quaternion Fourier transform (QFT), a generalization of the classical 2D Fourier transform, plays an increasingly active role in particular signal and colour image processing.
Cheng, Dong, Kou, Kit Ian
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

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