Results 81 to 90 of about 360,849 (311)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Non-Linear Dynamics Analysis of Protein Sequences. Application to CYP450
The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes ...
Xavier F. Cadet +3 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Distributed Digital Signal Processing Approach for Performance Enhancement of the Nodes in Wireless Sensor Networks [PDF]
As wireless sensors has to work very remotely, these suffers from less processing capability, insufficient available energy and transmission distance, suitable signal processing technology can offer efficient sensor network for certain remote application.
Kadlag, Swati
core +1 more source
Energy-Conscious Turbo Decoder Design: A Joint Signal Processing and Transmit Energy Reduction Approach [PDF]
Turbo codes (TCs) have been proposed to reduce the required transmission energy in wireless sensor networks (WSNs), although this gain must be offset by the turbo decoder's processing energy consumption (EC). Previously, it has not been possible to estimate this processing EC until a relatively late stage in the TC design process.
Liang Li 0013 +4 more
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
IEEE Transactions on Signal Processing [PDF]
We introduce a novel multichannel blind deconvolution (BD) method that extracts sparse and front-loaded impulse responses from the channel outputs, i.e., their convolutions with a single arbitrary source.
Pisupati, Pawan Bharadwaj +2 more
core +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source

