Results 101 to 110 of about 358,635 (311)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Hybrid Decision-Making Framework for Autonomous Vehicles in Urban Environments Based on Multi-Agent Reinforcement Learning with Explainable AI

Vehicles
Autonomous vehicles (AVs) are expected to operate safely and efficiently in complex urban environments characterized by dynamic and uncertain elements such as pedestrians, cyclists and adverse weather.
Ameni Ellouze, Mohamed Karray, Mohamed Ksantini   +2 more
doaj   +1 more source

Collaborative approach for energy cost minimization in smart grid communities

, 2017
In this paper we propose a novel demand side management method for minimizing the cost of electricity consumed by households from a smart community. Some households in the community may own renewable energy sources (RESs) and energy storing systems (ESSs)
Adriana Chi, Koivunen, Visa, Chis, Adriana, Visa Koivunen   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A NEW METHOD FOR SIDELOBE SUPPRESSION IN THE AMBIGUITY FUNCTION OF SIGNALS MODULATED BY PSEUDO-RANDOM SEQUENCES [PDF]

Radio Physics and Radio Astronomy
Subject and Purpose. One of the main challenges in achieving high-accuracy radar target parameter determination and improving radar system noise immunity is the presence of sidelobes in the ambiguity function of the used signals, especially when these ...
K. O. Lukin, V. M. Konovalov, L. V. Yurchenko   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

EC-CENTRIC: An Energy- and Context-Centric Perspective on IoT Systems and Protocol Design

IEEE Access, 2017
The radio transceiver of an Internet of Things (IoT) device is often where most of the energy is consumed. For this reason, most research so far has focused on low-power circuit and energy-efficient physical layer designs, with the goal of reducing the ...
Alessandro Biason, Chiara Pielli, Michele Rossi, Andrea Zanella, Davide Zordan, Mark Kelly, Michele Zorzi   +6 more
doaj   +1 more source

Distributed Asymptotic Minimization of Sequences of Convex Functions by a Broadcast Adaptive Subgradient Method [PDF]

, 2011
We propose a non-hierarchical decentralized algorithm for the asymptotic minimization of possibly time-varying convex functions. In our method, each agent in a network has a private, local (possibly time-varying) cost function, and the objective is to ...
Renato L. G. Cavalcante, Jennings, Nick, Isao Yamada, Cavalcante, Renato L. G., Rogers, A, Alex Rogers, Nicholas R. Jennings, Rogers, Alex, Yamada, I, Jennings, N, Yamada, Isao, Cavalcante, RLG   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Distributed Digital Signal Processing Approach for Performance Enhancement of the Nodes in Wireless Sensor Networks

, 2016
As wireless sensors has to work very remotely, these suffers from less processing capability, insufficient available energy and transmission distance, suitable signal processing technology can offer efficient sensor network for certain remote application.
Kadlag, Swati
core