Results 111 to 120 of about 358,635 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Quality-Aware Signal Processing Mechanism of PPG Signal for Long-Term Heart Rate Monitoring

Sensors
Photoplethysmography (PPG) is widely utilized in wearable healthcare devices due to its convenient measurement capabilities. However, the unrestricted behavior of users often introduces artifacts into the PPG signal.
Win-Ken Beh, Yu-Chia Yang, An-Yeu Wu
doaj   +1 more source

IEEE Transactions on Signal Processing

, 2019
We introduce a novel multichannel blind deconvolution (BD) method that extracts sparse and front-loaded impulse responses from the channel outputs, i.e., their convolutions with a single arbitrary source.
Pisupati, Pawan Bharadwaj, Fournier, Aime, Demanet, Laurent   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Development of FPGA-Based Data Acquisition System for Metallic Magnetic Calorimeter

Journal of Isotopes
Metallic magnetic calorimeters are a class of low-temperature particle detectors based on calorimetry，utilizing metallic paramagnetic temperature sensors to convert the temperature rise of an absorber upon the absorption of incident particle energy into ...
Yang LI, Lijun XU, Yuntao LIU, Baoji ZHU, Yuhe ZHANG, Qi JIN, Zongzheng ZHOU, Yuanqiao LI, Min LIN, Lijie HAO, Hongliang WANG, Shichun JIN   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Linear optical wave energy redistribution methods for photonic signal processing

npj Nanophotonics
Manipulating the phase of an optical wave over time and frequency gives full control to the user to implement a wide variety of energy preserving transformations directly in the analogue optical domain. These can be achieved using widely available linear
Connor Rowe, Xinyi Zhu, Benjamin Crockett, Geunweon Lim, Majid Goodarzi, Manuel Fernández, James van Howe, Hao Sun, Saket Kaushal, Afsaneh Shoeib, José Azaña   +10 more
doaj   +1 more source

Efficient FPGA implementation and power modelling of image and signal processing IP cores

, 2007
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Field Programmable Gate Arrays (FPGAs) are the technology of choice in a number ofimage and signal processing application areas such as consumer ...
Chandrasekaran, Shrutisagar
core  

On the Integration of Approximate Computing in GNSS Signal Processing for Improved Energy-Efficiency

Continuous miniaturization of GNSS receivers has led to reduction of energy consumption over the years. Yet, these remain one of the highest energy consuming sensors in embedded electronics, rendering their integration difficult in platforms with high ...
Ometov, Aleksandr, Lohan, Elena Simona, Nurmi, Jari, Grenier, Antoine   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source