Results 131 to 140 of about 360,849 (311)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Nonlinear Signal Processing Techniques for UWB Impulse Radios [PDF]
, 2017 Impulse Radio (IR) Ultra-wideband (UWB) communication is an attractive potential technology for low-power, low-complexity, and high-speed communications in short range links. One of the main challenges it faces is the highly frequency-selective multipath
Yang, Aidong
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Optimization-Based Mismatched-Channel Filtering Using ADMM for Continuous Active Sonar
Journal of Marine Science and EngineeringGeneralized Sinusoidal Frequency Modulation (GSFM) signals can enhance Continuous Active Sonar (CAS) performance by providing high sub-signal processing gain while achieving high target update rates.
Zitao Su, Juan Yang, Lu Yan
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Role of Free Energy Synchronization Signal in Translation of Prokaryotes [PDF]
, 2004 Sequences upstream of the coding region in prokaryotes show a consensus sequence called the Shine Dalgarno sequence. This sequence is the Watson-Crick complement to the 3' tail of 16S ribosomal RNA.
Mishra, Madhup
core
Author Correction: Full reconstruction of simplicial complexes from binary contagion and Ising data
Nature Communications, 2022 Huan Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Spatiotemporal Sensitive Network for Non-Contact Heart Rate Prediction from Facial Videos
Applied SciencesHeart rate (HR) is an important indicator reflecting the overall physical and mental health of the human body, playing a crucial role in diagnosing cardiovascular and neurological diseases.
Liying Su +8 more
doaj +1 more source