Results 121 to 130 of about 9,835,908 (287)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Concentration Uncertainty Principles for Signals on the Unit Sphere

, 2016
The uncertainty principle is an important and powerful tool, with many applications in signal processing. This paper presents two concentration uncertainty principles for signals on the sphere which relate the localization of the concentration of a ...
Khalid, Zubair, Durrani, Salman, Sadeghi, Parastoo, Kennedy, Rodney   +3 more
core   +1 more source

Energy Stealth Evaluation of Radar Systems with a Space–Time Modulated Probing Signal

Известия высших учебных заведений России: Радиоэлектроника
Introduction. Increased attention is currently paid to the issues of stealth operation of various radar systems. The article considers the possibility of increasing the energy stealth of a radar system with a complex quasi-continuous signal due to ...
V. M. Kutuzov, V. P. Ipatov, S. S. Sokolov   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Array and multichannel signal processing using nonparametric statistics [PDF]

, 2001
In array signal processing a group of sensors located at distinct spatial locations is deployed to measure a propagating wavefield. The multichannel output is then processed to provide information about parameters of interest.
Visuri, Samuli
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Optimization-Based Mismatched-Channel Filtering Using ADMM for Continuous Active Sonar

Journal of Marine Science and Engineering
Generalized Sinusoidal Frequency Modulation (GSFM) signals can enhance Continuous Active Sonar (CAS) performance by providing high sub-signal processing gain while achieving high target update rates.
Zitao Su, Juan Yang, Lu Yan
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Author Correction: Full reconstruction of simplicial complexes from binary contagion and Ising data

Nature Communications, 2022
Huan Wang, Chuang Ma, Han-Shuang Chen, Ying-Cheng Lai, Hai-Feng Zhang   +4 more
doaj   +1 more source