Results 81 to 90 of about 721,100 (302)

Alleviating oxygen evolution from Li-excess oxide materials through theory-guided surface protection

Nature Communications, 2018
Rechargeable Li-ion batteries can show extensive oxygen loss from the cathode material under operating conditions. Here, the authors use high-throughput computational screening to guide the synthesis of a Tantalum-doped Li-excess cathode that ...
Yongwoo Shin, Wang Hay Kan, Muratahan Aykol, Joseph K. Papp, Bryan D. McCloskey, Guoying Chen, Kristin A. Persson   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

2D materials for 1D electrochemical energy storage devices [PDF]

, 2019
One-dimensional (1D) electrochemical energy storage devices, such as fiber supercapacitors and cable-shaped batteries, are promising energy storage solutions for emerging wearable electronics due to their advantages in flexibility, weavability, and ...
Xuncai Chen, Junsheng Chen, Shengli Zhai, Wang, Xin, Chen, Yuan, Wang, Chaojun, Zhang, Xinshi, Yuan Chen, Chaojun Wang, Chen, Xuncai, Xinshi Zhang, Xin Wang, Chen, Junsheng, Zhai, Shengli, H. Enis Karahan, Karahan, Huseyin Enis, Li Wei, Wei, Li   +17 more
core   +1 more source

Switching Logic for a Direct Hybrid Electric Powertrain

Aerospace
Hybrid electric aircraft with a powertrain based on fuel cells and batteries can reduce climate-active emissions in aviation. In a direct hybrid powertrain, the fuel cell and the battery are connected in parallel, without a DC/DC converter balancing ...
Robin Fonk, Tobias Graf, Sven Paeßler, Christiane Bauer, Josef Kallo, Caroline Willich   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

CALiSol-23: Experimental electrolyte conductivity data for various Li-salts and solvent combinations

Scientific Data
Ion transport in non-aqueous electrolytes is crucial for high performance lithium-ion battery (LIB) development. The design of superior electrolytes requires extensive experimentation across the compositional space.
Paolo de Blasio, Jonas Elsborg, Tejs Vegge, Eibar Flores, Arghya Bhowmik   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Unifying the ORR and OER with surface oxygen and extracting their intrinsic activities on platinum

Nature Communications
Common half-cell measurements deliver oxygen reduction activities linked to the chosen scan rate, limiting their value for fundamental and comparative studies on platinum.
Benedikt Axel Brandes, Yogeshwaran Krishnan, Fabian Luca Buchauer, Heine Anton Hansen, Johan Hjelm   +4 more
doaj   +1 more source

Technical challenges and development prospects for capacity expansion and production ramp-up of depleted-reservoir-type gas storage facilities

You-qi chuyun
ObjectiveTo address the growing gap between China’s rapidly increasing demand for natural gas peak-shaving and the limited effective working gas volume of underground gas storage facilities, this study reviews the development of depleted-reservoir-type ...
Huohai YANG, Jia DENG, Jun HU, Xiaojian SU, Feng XU, Yuxia SHI, Siyuan ZHANG, Renze LI   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source