Results 61 to 70 of about 2,118,124 (289)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MaimAir: A flexible and modular energy storage system for tomorrow energy banks [PDF]
, 2016 We considered a novel energy storage system based on the compression of air through pumped water. Differently from CAES on trial, the proposed indirect compression leaves the opportunity to choose the kind of compression from adiabatic to isothermal. The
Fargion, Daniele, Habib, Emanuele
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Unifying the ORR and OER with surface oxygen and extracting their intrinsic activities on platinum
Nature CommunicationsCommon half-cell measurements deliver oxygen reduction activities linked to the chosen scan rate, limiting their value for fundamental and comparative studies on platinum.
Benedikt Axel Brandes +4 more
doaj +1 more source
Switching Logic for a Direct Hybrid Electric Powertrain
AerospaceHybrid electric aircraft with a powertrain based on fuel cells and batteries can reduce climate-active emissions in aviation. In a direct hybrid powertrain, the fuel cell and the battery are connected in parallel, without a DC/DC converter balancing ...
Robin Fonk +5 more
doaj +1 more source
Alleviating oxygen evolution from Li-excess oxide materials through theory-guided surface protection
Nature Communications, 2018 Rechargeable Li-ion batteries can show extensive oxygen loss from the cathode material under operating conditions. Here, the authors use high-throughput computational screening to guide the synthesis of a Tantalum-doped Li-excess cathode that ...
Yongwoo Shin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
CALiSol-23: Experimental electrolyte conductivity data for various Li-salts and solvent combinations
Scientific DataIon transport in non-aqueous electrolytes is crucial for high performance lithium-ion battery (LIB) development. The design of superior electrolytes requires extensive experimentation across the compositional space.
Paolo de Blasio +4 more
doaj +1 more source