Results 41 to 50 of about 1,992,116 (321)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

New Materials and New Configurations for Advanced Electrochemical Capacitors [PDF]

, 2008
Today, electrochemical capacitors (ECs) have the potential to emerge as a promising energy storage technology. The weakness of EC systems is certainly the limited energy density, which restricts applications to power delivery over only few seconds.
Naoi, Katsuhiko, Simon, Patrice
core  

Entropic Accelerating Universe [PDF]

, 2010
To accommodate the observed accelerated expansion of the universe, one popular idea is to invoke a driving term in the Friedmann-Lemaitre equation of dark energy which must then comprise 70% of the present cosmological energy density.
Baum, Damien A. Easson, Easson, Egan, Frampton, Friedmann, George F. Smoot, Hawking, Lemaître, Padmanabhan, Paul H. Frampton, Perlmutter, Reiss, Riess, Tolman, Tolman, Unruh, Verlinde   +17 more
core   +5 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Atomic-scale combination of germanium-zinc nanofibers for structural and electrochemical evolution [PDF]

, 2019
Alloys are recently receiving considerable attention in the community of rechargeable batteries as possible alternatives to carbonaceous negative electrodes; however, challenges remain for the practical utilization of these materials.
AS Arico, AV Chadwick, BR Wang, D Li, DR Kumar, GA Agarkova, I Son, J Echeverria, J Hwang, J Lee, J Liu, J Lu, J Mizusaki, J Ryu, J Yang, J Zhao, JH Strange, JI Lee, JJ Gao, JY Cheong, KH Seng, L Qian, LY Lim, MH Hsieh, MH Park, MS Wang, N Nitta, P Hidalgo, RW Mo, S Choi, S Yoon, SP Wu, TH Kim, W He, W Xiao, WH Li, XH Liu, XL Wang, XS Liu, Y An, Y An, Y An, Y An, Y An, Y An, Y Sun, Y Yuan., YH Xie, YW Lee   +48 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimization of energy storage density in ceramic capacitors

Journal of Physics D: Applied Physics, 1996
A theoretical treatment, based on the Devonshire theory of ferroelectrics, is presented to describe the storage of electrostatic energy in ferroelectric and paraelectric materials at very high field strengths. In all cases, optimal energy density is achieved by using compositions with Curie temperatures well below the operating temperature.
Fletcher, Neville H., Hilton, A D, Ricketts, B W   +2 more
openaire   +2 more sources

Newly discovered failure mode in high energy density, energy storage capacitors [PDF]

, 1978
High energy density pulse capacitors, typified by the 10-kV, 170-..mu..F unit, have become widely used in recent years. These units primarily were designed for lower cost and higher energy per unit volume. The life characteristics of these units have never been determined fully, but they have already been shown capable of lives much longer than ...
Boicourt, G. P., Kemp, E. L.
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source