Results 41 to 50 of about 243,884 (264)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Rapid and stable calcium-looping solar thermochemical energy storage via co-doping binary sulfate and Al–Mn–Fe oxides

Green Energy & Environment
Solar thermochemical energy storage based on calcium looping (CaL) process is a promising technology for next-generation concentrated solar power (CSP) systems.
Changjian Yuan, Xianglei Liu, Xinrui Wang, Chao Song, Hangbin Zheng, Cheng Tian, Ke Gao, Nan Sun, Zhixing Jiang, Yimin Xuan, Yulong Ding   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Excellent energy storage properties in lead-free ferroelectric ceramics via heterogeneous structure design

Nature Communications
Dielectric capacitors with ultrahigh power density have emerged as promising candidates for essential energy storage components in electronic and electrical systems. They enable enhanced integration, miniaturization, and lightweight design.
Qizhen Chai, Zhaobo Liu, Zhongqi Deng, Zhanhui Peng, Xiaolian Chao, Jiangbo Lu, Houbing Huang, Shujun Zhang, Zupei Yang   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mg-Based Hydrogen Absorbing Materials for Thermal Energy Storage—A Review

Applied Sciences, 2018
Utilization of renewable energy such as solar, wind, and geothermal power, appears to be the most promising solution for the development of sustainable energy systems without using fossil fuels.
Bo Li, Jianding Li, Huaiyu Shao, Liqing He   +3 more
doaj   +1 more source

Energy Efficiency Comparison of Hydraulic Accumulators and Ultracapacitors

Energies, 2020
Energy regeneration systems are a key factor for improving energy efficiency in electrohydraulic machinery. This paper is focused on the study of electric energy storage systems (EESS) and hydraulic energy storage systems (HESS) for energy regeneration ...
Jorge Leon-Quiroga, Brittany Newell, Mahesh Krishnamurthy, Andres Gonzalez-Mancera, Jose Garcia-Bravo   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Machine‐Learning‐Guided Design of Incommensurate Antiferroelectrics via Field‐Driven Phase Engineering

Advanced Science
Antiferroelectrics, defined by antiparallel polarization configurations, have emerged as promising dielectric materials for high‐performance energy storage applications.
Ke Xu, Xiaoming Shi, Zhaochen Xi, Shouzhe Dong, Changqing Guo, Rongzhen Gao, Letao Yang, Jing Wang, Di Zhou, Houbing Huang   +9 more
doaj   +1 more source