Results 61 to 70 of about 22,602,092 (252)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Sleep Staging Method Based on Multimodal Physiological Signals Using Snake–ACO

Applied Sciences
Non-invasive electrocardiogram (ECG) and respiratory signals are easy to acquire via low-cost sensors, making them promising alternatives for sleep staging. However, existing methods using these signals often yield insufficient accuracy.
Wenjing Chu, Chen Wang, Liuwang Yang, Lin Guo, Chuquan Wu, Binhui Wang, Xiangkui Wan   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Improving forecasting accuracy of renewable energy generation via periodicity-aware deep learning framework with Time2Vec

Green Energy and Intelligent Transportation
Accurate forecasting of photovoltaic (PV) and wind power generation is vital for reliable renewable energy operations. However, their differing temporal characteristics, especially in periodicity, pose challenges for unified prediction models. This paper
Hang Wan, Jiasong Wang, Quan Gan, Rui Quan, Yaping Xia, Sara Himmiche, Yufang Chang   +6 more
doaj   +1 more source

Application of Game Theory in Integrated Energy System Systems: A Review

IEEE Access, 2020
With the rapid development of society, global energy is in short supply. China has put forward an integrated energy system focusing on interconnecting energy resources and harnessing their complementary advantages to address the energy crisis, thus no ...
Jun He, Yi Li, Huangqiang Li, Huamin Tong, Zhijun Yuan, Xiaoling Yang, Wentao Huang   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Integrating Compressed CO2 Energy Storage in an Integrated Energy System

The integration of an energy storage system into an integrated energy system (IES) enhances renewable energy penetration while catering to diverse energy loads.
Qingxi Huang, Xiaohan Ren, Yongxin Song, Wei Wang, Qie Sun   +4 more
core   +1 more source

Many-objective bi-level energy scheduling method for integrated energy stations based on power allocation strategy

iScience
Summary: The integrated energy station of new energy vehicle hydrogenation/charging/power exchange is proposed, which also includes hydrogen production, hydrogen storage, electricity sales to users and the grid (WPIES).
Xiang Liao, Jun Ma, Bangli Yin, Beibei Qian, Runjie Lei, Fu B, Chaoshun Li   +6 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source