Results 91 to 100 of about 249,548 (304)

Energy Sustainability

, 2022
Energy Sustainability has been addressed through advancing technology efficiency, which may increase the impact of the use of natural resources. However, the increase in efficiency makes services cheaper, which causes a rebound effect, direct or indirect, on energy consumption and materials. Moreover, the popular concept of recycling seems insufficient
Flores, João, Cavique, Miguel, Seixas, Júlia   +2 more
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Thermal Storage Systems Assessment for Energy Sustainability in Housing Units

, 2016
In order to achieve greater enhancements in energy sustainability for housing, the function and efficiency of two different passive cooling systems were studied: encapsulated water in recycled bottles of Polyethylene terephthalate (PET) and polystyrene ...
Ricardo Campos Campos, Oscar Velazquez Camilo, Ma Diaz Vega, Sergio Zamora Castro, Tania Lagunes Vega   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rethinking Sustainability within the Viticulture Realities Integrating Economy, Landscape and Energy

, 2018
Sustainability is often explained through three dimensions (society, economy and environment). However, such a definition currently appears to be restricted. Sustainable development often includes the energy issue.
Andrea Colantoni, Enrico Mosconi, Ilaria Zambon, Massimo Cecchini   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Emergy and Sustainability Ternary Diagrams of Energy Systems: Application to Solar Updraft Tower

, 2020
To facilitate sustainable energy development, one has to understand the limited availability of nonrenewable energy resources, and the ability of the earth to renew or recover.
Yoshiki Nishi, Islam Elsayed
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Towards Sustainable Wood-Based Energy: Evaluation and Strategies for Mainstreaming Sustainability in the Sector

, 2019
Bioenergy, mostly from wood biomass, is now widely seen as an important element in the efforts to tame dangerous climate change. At the same time, foresters and development specialists note that wood-based energy production can contribute to rural ...
Julia Szulecka, Szulecka, Julia
core   +1 more source

Charge-specific size-dependent separation of water-soluble organic molecules by fluorinated nanoporous networks

Nature Communications, 2016
Porous materials for aqueous contaminant removal are common, but there are few examples of size and charge-dependent separation. Here, the authors report the charge-specific size-dependent separation of water-soluble molecules through a polymeric network
Jeehye Byun, Hasmukh A. Patel, Damien Thirion, Cafer T. Yavuz   +3 more
doaj   +1 more source