Results 81 to 90 of about 249,548 (304)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Energy and sustainability [PDF]

Clean Technologies and Environmental Policy, 2017
Galen J. Suppes, Truman S. Storvick
  +5 more sources

First detection of industrial hydrogen emissions using high precision mobile measurements in ambient air

Scientific Reports
Projections towards 2050 of the global hydrogen (H2) demand indicate an eight-fold increase in present-day hydrogen consumption. Leakage during production, transport, and consumption therefore presents a large potential for increases in the atmospheric ...
Iris M. Westra, Hubertus A. Scheeren, Firmin T. Stroo, Steven M. A. C. van Heuven, Bert A. M. Kers, Wouter Peters, Harro A. J. Meijer   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Methodology for the use of aerial thermography as a validation method for outdoor thermal comfort simulations

Energy Conversion and Management: X
The urban heat island (UHI) effect underscores the importance of outdoor spaces in urban planning and design, where thermal comfort has become a critical consideration.
V.P. Lopez-Cabeza, M. Videras-Rodriguez, S. Gomez-Melgar, J.M. Andujar-Marquez   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessing the sustainability of biomass supply chains for energy exploitation

, 2014
Biomass use has increased significantly lately, partly due to conventional fuels price increase. This trend is more evident in rural areas with significant local biomass availability. Biomass may be used in various ways to generate heat.
Rentizelas, Athanasios
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Preferences matter: A constructive approach to incorporating local stakeholders' preferences in the sustainability evaluation of energy technologies [PDF]

, 2015
This research paper aims at developing and applying a constructive weighting methodology for the elicitation of local stakeholders' preferences regarding a set of sustainability evaluation criteria during the assessment of low-carbon energy technologies.
Elena Enseñado, Stelios Grafakos, Enseñado, E.M. (Elena Marie), Grafakos, S. (Stelios), Alexandros Flamos, Flamos, A. (Alexandros)   +5 more
core   +1 more source

Hydrogen Generation and Serpentinization of Olivine Under Flow Conditions

Geophysical Research Letters
Serpentinization of olivine is often studied in the laboratory under batch conditions. Olivine conversion in situ with enhanced natural hydrogen production will likely be implemented via injection of aqueous solutions. Hence, transport is relevant to the
C. M. Ross, B. Vega, L. Frouté, T.‐W. Kim, A. R. Kovscek   +4 more
doaj   +1 more source