Results 131 to 140 of about 136,814 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Towards a more collaborative energy system modelling for addressing Europe's energy transition challenges.

, 2023
In this paper, we argue that the current modelling toolbox behind the REPowerEU plan and national energy and climate plans should be expanded. In a second chapter, we illustrate how energy system research institutes can step in to provide model scenarios
Calis, Gulben, Vingerhoets, Pieter, Perissi, Ilaria, Graabak, Ingeborg, Garcia-Gusano, Diego, Strbac, Goran, Morales, German, Seljom, Pernille, Mayo-Garcia, Rafael, Jochem, Patrick, Madsen, Henrik, Thiene, Mara, Perez, Yolanda Lechon, Vries, Laurens de, Tahavori, Amin Mohammad, Bruninx, Kenneth, Simoes, Sofia, Jones, Aled, Støa, Petter, Pflugradt, Noah, del Granado, Pedro Crespo, Dent, Chris J., Kiviluoma, Juha, Arango, Diego Tejada, Gladkykh, Ganna, Sijm, Jos, Keles, Dogan, Belsnes, Michael, Mathisen, Siri, Jager, Wander   +29 more
core  

Advances and visions in large-scale hydrological modelling : findings from the 11th Workshop on Large-Scale Hydrological Modelling [PDF]

, 2008
Large-scale hydrological modelling has become increasingly wide-spread during the last decade. An annual workshop series on large-scale hydrological modelling has provided, since 1997, a forum to the German-speaking community for discussing recent ...
K. Berkhoff, P. Döll, Fohrer, N., Hagemann, S., Krol, Martinus S., Fohrer, Nicola, Hagemann, Stefan, M. Krol, H. Bormann, D. Gerten, Bormann, H., Berkhoff, Karin, Bormann, Helge, S. Hagemann, Gerten, Dieter, Gerten, D., N. Fohrer, Krol, M., Döll, P., Döll, Petra, Krol, Maarten, Berkhoff, K.   +21 more
core   +1 more source

Energy Modelling and Analysis for Sustainable Energy System of Somalia

Energy Science & Engineering
To ensure sustainable management of energy systems and maintain their benefits over time, it's imperative to prioritise science‐based decision‐making models throughout energy policy formulation and management processes, however, there is a significant ...
Abdisalan Moallim Hirsi, Shoaib Ahmed Khatri, Nayyar Hussain Mirjat, Musavir Hussain, Laveet Kumar, MD Shouquat Hossain   +5 more
doaj   +1 more source

A Techno-Economic Study of an Entirely Renewable Energy-Based Power Supply for North America for 2030 Conditions

Energies, 2017
In this study power generation and demand are matched through a least-cost mix of renewable energy (RE) resources and storage technologies for North America by 2030.
Arman Aghahosseini, Dmitrii Bogdanov, Christian Breyer   +2 more
doaj   +1 more source

Using the max-p regions problem algorithm to define regions for energy system modelling. [PDF]

MethodsX, 2021
Fleischer CE.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modeling of Hydro-Pneumatic Energy Storage Using Pump Turbines [PDF]

, 2011
Modelling of a hydro-pneumatic energy storage system is presented in this paper. Hydro pneumatic storage aims to combine the good efficiency of hydraulic energy conversion and the space flexibility of pneumatic storage.
COLAS, Frédéric, DAZIN, Antoine, ORTEGO, Egoï, CAIGNAERT, Guy, COUTIER-DELGOSHA, Olivier   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Energy, carbon and cost performance of building stocks : upgrade analysis, energy labelling and national policy development

, 2009
The area of policy formulation for the energy and carbon performance of buildings is coming under increasing focus. A major challenge is to account for the large variation within building stocks relative to factors such as location, climate, age ...
Kim, J.M., Tuohy, P.G., Johnstone, C., Clarke, J.A.   +3 more
core   +1 more source