Results 101 to 110 of about 12,414,527 (394)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Performance Analysis and Rapid Optimization of Vehicle ORC Systems Based on Numerical Simulation and Machine Learning

open access: yesEnergies
The organic Rankine cycle (ORC) system is an important technology for recovering energy from the waste heat of internal combustion engines, which is of significant importance for the improvement of fuel utilization. This study analyses the performance of
Xin Wang   +5 more
doaj   +1 more source

Pair Scattering of Electrons in Edge Channels of Opposite Chiralities in the Presence of a Disorder Potential

open access: yes, 2012
The nonequilibrium transfer of the energy between electrons of counter-propagating quasi-one-dimensional systems has been perturbatively calculated for edge channels in a two-dimensional system in the integer quantum Hall effect.
Khrapai, V. S., Prokudina, M. G.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Performance and Stability Analysis of A Hydrogen Production System Based on Solar Electrolysis of Water

open access: yes南方能源建设
[Objective] The hydrogen production system based on solar electrolysis of water is limited by the volatility and intermittency of solar energy, the conversion efficiency of the photovoltaic system, and the performance of the electrolysis cell.
Mengwei MIAO   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Electrochemical Fabrication of rGO-embedded Ag-TiO2 Nanoring/Nanotube Arrays for Plasmonic Solar Water Splitting

open access: yesNano-Micro Letters, 2019
Effective utilization of hot electrons generated from the decay of surface plasmon resonance in metal nanoparticles is conductive to improve solar water splitting efficiency.
Lixia Sang, Lei Lei, Clemens Burda
doaj   +1 more source

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