Results 71 to 80 of about 657,721 (268)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Energy-saving renovation of old urban buildings: A case study of Beijing

open access: yesCase Studies in Thermal Engineering, 2021
Energy saving and environmental protection have become the core development concept of China construction industry. There are still a large number of old urban buildings in Beijing, whose energy consumption far exceeds the current building energy ...
Xinxin Zhang   +3 more
doaj  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Charging system analysis, energy consumption, and carbon dioxide emissions of battery electric buses in Beijing

open access: yesCase Studies in Thermal Engineering, 2021
Bus rides have become a routine choice for the large population to travel in Beijing. By the end of November 2020, 82.84% of all buses in Beijing had switched to electric vehicles.
Xinxin Zhang   +3 more
doaj  

Experimental Study on Temperature Distribution and Heat Losses of a Molten Salt Heat Storage Tank

open access: yesEnergies, 2019
Two-tank molten salt heat storage systems are considered to be the most mature thermal storage technology in solar thermal power plants. As the key part of the system, the thermal performance of molten salt tanks is of great importance.
Xiaoming Zhang   +5 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

What can Beijing learn from the world megacities on energy and environmental issues?

open access: yesEnergy Reports, 2022
In order to build Beijing into a world-class harmonious and livable capital city, its energy and environmental issues deserve special attention. Considering London’s experience and achievements in tackling smog crisis, New York’s world-class city ...
Xinxin Zhang   +3 more
doaj  

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