Results 111 to 120 of about 10,533,673 (391)
Sustainability, 2020 In order to analyse long-term transformation pathways, energy system models generally focus on economical and technical characteristics. However, these models usually do not consider sustainability aspects such as environmental impacts. In contrast, life
T. Junne +7 more
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The effective hyper-K"ahler potential in the N=2 supersymmetric QCD
, 1997 The effective low-energy hyper-K"ahler potential for a massive N=2 matter in the N=2 super-QCD is investigated. The N=2 extended supersymmetry severely restricts that N=2 matter self-couplings so that their exact form can be fixed by a few parameters ...
Affleck +28 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Low Energy Action of "Covariant" Superstring Field Theory in the NS-NS pp-Wave Background
, 2011 Exact construction of superstring field theory in some background fields is very important. We construct the low energy NS-NS sector of superstring field action in the pp-wave background with the flux of NS-NS antisymmetric tensor field (NS-NS pp-wave ...
Pankiewicz A. +4 more
core +1 more source
, 2020 A comprehensive numerical study on flow-induced motions (FIMs) of a deep-draft semi-submersible, a typical multiple cylindrical structure in offshore engineering, was carried out to investigate the energy transformation of the vortex shedding process. In
L. Tao
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Humanities & Social Sciences Communications, 2020 Within the energy geographies debate on the uneven scalar effects of energy transitions, this article addresses the under-examined, increasing intersection of automation and energy transitions.
Siddharth Sareen
doaj +1 more source
A new world : the geopolitics of the energy transformation [PDF]
, 2019 Aware that the growing deployment of renewables has set in motion a global energy transformation with significant implications for geopolitics, Adnan Z. Amin, the Director-General of the International Renewable Energy Agency (IRENA), with the support of ...
Global Commission on the Geopolitics of Energy Transformation, The secretariat of the +1 more
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