Results 141 to 150 of about 10,205,958 (357)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Energy efficiency compared studies at Master plan stage for a new urban development in Madrid

open access: yes, 2008
In order to achieve optimum results, energy efficiency of buildings should be first addressed in the pre-design phase. This paper describes the studies carried out in order to improve the energy efficiency of the buildings planned to be built in a large ...
Rodríguez, Francisco   +3 more
core  

Decision Process for Identifying Appropriate Devices for Power Transfer between Voltage Levels in Distribution Grids

open access: yesEnergies
During the energy transition, new types of electrical equipment, especially power electronic devices, are proposed to increase the flexibility of electricity distribution grids.
Nassipkul Dyussembekova   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Fun Science Teaching Materials on the Energy Transformation to Promote Students’ Scientific Literacy

open access: yes, 2019
This study aims to develop fun science teaching material on the energy transformation to promote scientific literacy of junior high school students. The research is a four-D design of Research and Development.
I. D. Pursitasari   +2 more
semanticscholar   +1 more source

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