Results 151 to 160 of about 10,205,958 (357)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Spatio-temporal load shifting for truly clean computing
Advances in Applied EnergyCompanies operating datacenters are increasingly committed to procuring renewable energy to reduce their carbon footprint, with a growing emphasis on achieving 24/7 Carbon-Free Energy (CFE) matching—eliminating carbon emissions from electricity use on an
Iegor Riepin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Analysis of Mechanical Properties of Steel Tube Crossing Frame for Power Transmission Project
MetalsIn this study, compared with traditional scaffolds, the arrangement and structural dimensions of steel tubular crossing frames used in transmission engineering are significantly different, making it difficult to efficiently and accurately evaluate their ...
Shuang Wang +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Impact of Power Quality on the Efficiency of the Mining Process
EnergiesThere are currently more than 30 underground mines operating in Poland. These are mines extracting hard coal, salt, and metal ores. Each of these plants has its own specifics for operation, but all operate under the same regulations.
Tomasz Siostrzonek +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2019 Thanks to the European Union’s policy pressure, the EU energy system is going through increasing decentralisation and decarbonisation processes. Digitalisation, in this context, is a key enabler, as it unlocks opportunities for actors across the value ...
Franco Fumiatti (Tractebel) +10 more
core +1 more source
Applied SciencesWheeled multifunctional motorized crossing frames represent a new type of crossing equipment for high-voltage transmission line construction. The initial design is too conservative, having a large safety margin and high material redundancy. Therefore, it
Shuang Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source