Results 61 to 70 of about 7,421,696 (299)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A new world : the geopolitics of the energy transformation [PDF]

, 2019
Aware that the growing deployment of renewables has set in motion a global energy transformation with significant implications for geopolitics, Adnan Z. Amin, the Director-General of the International Renewable Energy Agency (IRENA), with the support of ...
Van de Graaf, Thijs, Global Commission on the Geopolitics of Energy Transformation, The secretariat of the   +1 more
core  

An energy-efficient predictive control for HVAC systems applied to tertiary buildings based on regression techniques

, 2017
Publisher Copyright: © 2017 Elsevier B.V.Heating ventilation and air conditioning (HVAC) systems represent an important amount of the total energy use in office buildings, accounting for near 30%.
Gil-Lopez, Sergio, Manjarres, Diana, Ana Mera, Eugenio Perea, Perea, Eugenio, Lejarazu, Adelaida, Sergio Gil-Lopez, Diana Manjarres, Mera, Ana, Adelaida Lejarazu   +9 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Projected Benefits of Federal Energy Efficiency and Renewable Energy Programs: FY 2005 Budget Request

, 2004
The Office of Energy Efficiency and Renewable Energy (EERE) of the U.S. Department of Energy (DOE) leads the Federal Government's efforts to provide reliable, affordable, and environmentally sound energy for America, through its 11 research, development,
Laboratory, National Renewable Energy
core   +1 more source

The Research Progress of Monoclonal Antibody Labeled with 89Zr

Journal of Isotopes
Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission ...
Zhanxiong XIAO, Fei DUAN, Hongyu LI
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Technical and Economic Aspects of Using DC or AC Motors in the Drive of Hoisting Machines

Energies
A hoisting machine is one of the main components of an underground mine process line. The drive systems currently used in these machines are based on direct current, synchronous, or induction (AC) motors. Power electronic converters are used to power and
Tomasz Siostrzonek, Jacek Pytel, Tomasz Karpiel   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source