Results 81 to 90 of about 379,777 (267)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Decision Process for Identifying Appropriate Devices for Power Transfer between Voltage Levels in Distribution Grids

open access: yesEnergies
During the energy transition, new types of electrical equipment, especially power electronic devices, are proposed to increase the flexibility of electricity distribution grids.
Nassipkul Dyussembekova   +3 more
doaj   +1 more source

Trust and the transformation of energy systems

open access: yesEnergy Policy, 2010
The author looks at diverse concepts and roles of trust in the challenge of decarbonising energy systems, drawing on 25 years of personal experience in the fields of energy and environmental policy research. The paper focuses on three issues-public trust in science, institutional trust in making technology choices, and the idea that high-trust ...
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Spatio-temporal load shifting for truly clean computing

open access: yesAdvances in Applied Energy
Companies operating datacenters are increasingly committed to procuring renewable energy to reduce their carbon footprint, with a growing emphasis on achieving 24/7 Carbon-Free Energy (CFE) matching—eliminating carbon emissions from electricity use on an
Iegor Riepin   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Analysis of Mechanical Properties of Steel Tube Crossing Frame for Power Transmission Project

open access: yesMetals
In this study, compared with traditional scaffolds, the arrangement and structural dimensions of steel tubular crossing frames used in transmission engineering are significantly different, making it difficult to efficiently and accurately evaluate their ...
Shuang Wang   +5 more
doaj   +1 more source

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