Results 61 to 70 of about 614,636 (258)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Prediction of fire danger index using a new machine learning based method to enhance power system resiliency against wildfires

IET Generation, Transmission & Distribution
Wildfires, which can cause significant damage to power systems, are mostly inevitable and unpredictable. Fire danger indexes, such as the Forest Fire Danger Index (FFDI) and the Canadian Fire Weather Index (FWI), measure the potential wildfire danger at ...
Tan Nhat Pham, Rakibuzzaman Shah, Nima Amjady, Syed Islam   +3 more
doaj   +1 more source

Application of Energy Storage Systems to Enhance Power System Resilience: A Critical Review

Energies
The growing frequency and severity of extreme events, both natural and human-induced, have heightened concerns about the resilience of power systems.
Muhammad Usman Aslam, Md Sazal Miah, B. M. Ruhul Amin, Rakibuzzaman Shah, Nima Amjady   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimization of Well Locations and Trajectories: Comparing Sub-Vertical, Sub-Horizontal and Multi-Lateral Well Concepts for Marginal Geothermal Reservoir in The Netherlands

Energies
Scaling up the direct use of geothermal heat in urban areas comes with the challenge of enabling the development of projects in geological settings where geothermal reservoir flow properties may be poor, resulting in low well flow performance.
Eduardo G. D. Barros, Slawomir P. Szklarz, Negar Khoshnevis Gargar, Jens Wollenweber, Jan Diederik van Wees   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Australian fire weather variability using calibrated long-term reanalysis data

Discover Environment
Spatiotemporal variability on multi-decadal time scales can be observed in weather conditions associated with wildfires. The climatic factors that drive this variability in fire weather conditions have been studied using bias-corrected 20th Century ...
Soubhik Biswas, Savin S. Chand, Andrew J. Dowdy, Krishneel Sharma   +3 more
doaj   +1 more source

Aggregation of Distributed Energy Resources and Energy Storage Systems in Active Distribution Networks: A Critical Review

Energies
The transition of modern power systems is going through the challenges of uncertainties originating from equipment unavailability, forecasting errors, market fluctuations, prosumer behaviors, regulatory and policy changes, and extreme weather conditions.
Pranta Dash Gupta, Najma Habeeb, Rakibuzzaman Shah, Nima Amjady   +3 more
doaj   +1 more source

Experimental analysis of a horizontal-axis wind turbine with swept blades using PIV data [PDF]

Wind Energy Science
This study presents findings from a wind tunnel experiment investigating a model wind turbine equipped with aft-swept blades. Utilising particle image velocimetry, velocity fields were measured at multiple radial stations.
E. Fritz, E. Fritz, K. Boorsma, C. Ferreira   +3 more
doaj   +1 more source