Results 61 to 70 of about 2,959,388 (279)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Hierarchical Random Energy Model

, 2010
We introduce a Random Energy Model on a hierarchical lattice where the interaction strength between variables is a decreasing function of their mutual hierarchical distance, making it a non-mean field model.
Aurélien Decelle, C. De Dominicis, Giorgio Parisi, Marc Mézard, Michele Castellana, P. Collet, Silvio Franz   +6 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Prospects for offshore hydrogen production in the Netherlands

Environmental Research: Energy
Using a technology-rich optimization model for the Netherlands, we analyse the potential role of offshore energy options for system integration purposes.
Joost van Stralen, Gaby Janssen, Joris Koornneef, Martin Scheepers, Jeffrey Sipma, Bob van der Zwaan   +5 more
doaj   +1 more source

Hagedorn transition for strings on pp-waves and tori with chemical potentials

, 2002
It has been conjectured that string theory in a pp-wave background is dual to a sector of N=4 supersymmetric Yang-Mills theory. We study the Hagedorn transition for free strings in this background.
Alford, Alvarez, Alvarez, Atick, Berenstein, Bertolini, Bowick, Bowick, Brandenberger, Brower, Burgess, Caldarelli, Chung-I Tan, David A. Lowe, Deo, Deo, Deo, Greene, Hagedorn, Hawking, Hubeny, Kim, Kogan, Landsteiner, Lowe, Maldacena, McClain, Mitchell, Mukhi, O'Brien, Pando Zayas, Pando Zayas, Polchinski, Polyakov, Polyakov, Rajagopal, Rama, Richard C. Brower, Sathiapalan, Sugawara, Sundborg, Sundborg, Takayanagi, Tye, Witten, Witten   +45 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Wildfire Impacts on Security of Electric Power Systems: A Survey of Risk Identification and Mitigation Approaches

IEEE Access
The increase of extremely hot days globally has led to more frequent wildfires and frequent power outages directly and indirectly caused by the wildfires.
Rakibuzzaman Shah, Nima Amjady, Nusrat Subah Binte Shakhawat, Muhammad Usman Aslam, MD. Sazal Miah   +4 more
doaj   +1 more source

T=0 heavy fermion quantum critical point as an orbital selective Mott transition

, 2009
We describe the T=0 quantum phase transition in heavy fermion systems as an orbital selective Mott transition (OSMT) using a cluster extension of dynamical mean field theory.
Civelli, Marcello, De Leo, Lorenzo, Kotliar, Gabriel   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source