Results 41 to 50 of about 874,388 (342)

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

Infarto cerebral embólico de origen no determinado: más allá de la fibrilación auricular

Neurología, 2022
Resumen: Introducción: El infarto cerebral embólico de origen no determinado (ESUS por sus siglas en inglés) representa el 25% de todos los infartos cerebrales y solo el 30% se asocia con fibrilación auricular (FA) paroxística.
A. Arauz, C. Arteaga, C. Zapata-Gómez, C. Ramos-Ventura, B. Méndez, R. Otiniano-Sifuentes, S. Haseeb, R. González-Oscoy, A. Baranchuk   +8 more
doaj  

Medicine 5th course student’s attitudes towards mental health [PDF]

, 2012
Introducción. El estigma social que persiste hacia la enfermedad mental puede estar presente en los estudiantes de medicina e impactar en la forma de considerar ésta y la psiquiatría como especialidad. Objetivo.
Caballero, Luis, Failde Martínez, Inmaculada, Gilaberte, Inmaculada, Salazar Couso, Alejandro   +3 more
core   +2 more sources

ENFERMEDAD DE BUERGER

Revista Clínica Escuela de Medicina UCR-HSJD, 2011
La tromboangeítis obliterante o más ampliamente conocida como Enfermedad de Buerger es unaenfermedad segmentaria, inflamatoria, oclusiva,no aterosclerótica que compromete las arterias demediano y pequeño calibre, venas y nervios; queafecta predominantemente a pacientes jóvenes,masculinos y con historia de abuso de tabaco.
Cascante Quirós, Ana Yanci, Mesén Ramírez, Jorge, Jiménez Juárez, Róger   +2 more
openaire   +6 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Development and evaluation of a duplex TaqMan qPCR assay for detection and quantification of Trypanosoma cruzi infection in domestic and sylvatic reservoir hosts

Parasites & Vectors, 2019
Background A question of epidemiological relevance in Chagas disease studies is to understand Trypanosoma cruzi transmission cycles and trace the origins of (re)emerging cases in areas under vector or disease surveillance.
Diana P. Wehrendt, Andrea Gómez-Bravo, Juan C. Ramirez, Carolina Cura, Angélica Pech-May, Janine M. Ramsey, Marcelo Abril, Felipe Guhl, Alejandro G. Schijman   +8 more
doaj   +1 more source

Association Between Sleep Disturbance and Subsequent Pain Interference in Patients With Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated whether sleep disturbance can predict the extent to which pain interferes with daily functioning in patients with early rheumatoid arthritis (RA). Methods Data were from adults with early RA (joint symptoms ≤12 months) enrolled in the Canadian Early Arthritis Cohort between 2016 and 2023.
Burcu Aydemir, Orit Schieir, Marie‐France Valois, Lutfiyya N. Muhammad, Jing Song, Dorothy Dunlop, Rowland W. Chang, Susan J. Bartlett, Louis Bessette, Gilles Boire, Glen Hazlewood, Carol Hitchon, Janet Pope, Carter Thorne, Diane Tin, Vivian P. Bykerk, Yvonne C. Lee   +16 more
wiley   +1 more source

Sleep Matters: Exploring the Link Between Sleep Disturbances and Fatigue in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Fatigue is a prevalent and debilitating symptom for patients with rheumatoid arthritis (RA). Although patients and rheumatologists often attribute fatigue to inflammation, other factors such as sleep disturbances are frequently overlooked. This study aims to explore the relationship between subjective (self‐reported) and objective (actigraphy
Natalia V. Chalupczak, Burcu Aydemir, Ariel Isaacs, Lutfiyya N. Muhammad, Jing Song, Kathryn J. Reid, Daniela Grimaldi, Mary Carns, Kathleen Dennis‐Aren, Dorothy D. Dunlop, Beth I. Wallace, Phyllis C. Zee, Yvonne C. Lee   +12 more
wiley   +1 more source

Diagnóstico y tratamiento de la enfermedad inflamatoria intestinal: Primer Consenso Latinoamericano de la Pan American Crohn's and Colitis Organisation

Revista de Gastroenterología de México, 2017
La incidencia y la prevalencia de la enfermedad inflamatoria intestinal (EII) se han incrementado en los últimos años en varios países de Latinoamérica. Existe una necesidad de concientizar a gastroenterólogos y a la población en general para poder tener
J.K. Yamamoto-Furusho, F. Bosques-Padilla, J. de-Paula, M.T. Galiano, P. Ibañez, F. Juliao, P.G. Kotze, J.L. Rocha, F. Steinwurz, G. Veitia, C. Zaltman   +10 more
doaj   +1 more source