Results 31 to 40 of about 5,120 (205)

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante, Lídia Vaqué‐Alcázar, Mateus Rozalem‐Aranha, José Allende Parra, Zili Zhao, Javier Arranz, Íñigo Rodríguez‐Baz, Lucia Maure‐Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Miguel Santos‐Santos, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +27 more
wiley   +1 more source

In vivo mapping of cortical amyloid beta‐myelin coupling in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Accumulating evidence suggests that amyloid‐β (Aβ) preferentially deposits in poorly myelinated cortical regions and may interfere with remyelination. We hypothesized that this vulnerability would manifest as altered Aβ–myelin coupling in preclinical Alzheimer's disease (AD).
Mercedes Atienza, Jose L. Cantero
wiley   +1 more source

Potencial terapéutico de las células madre en la enfermedad cerebrovascular

, 2022
La enfermedad cerebrovascular es una importante causa de muerte e incapacidad en todo el mundo. Esta enfermedad es consecuencia de un complejo grupo de procesos fisiopatológicos que afectan la vasculatura del sistema nervioso, resultando en isquemia y ...
Villa-Delgado, Rosmery, Sabogal-Barrios, Rubén, Alcalá-Cerra, Gabriel, Moscote-Salazar, Luis Rafael   +3 more
core   +1 more source

Relación urea-creatinina como factor pronóstico en la enfermedad cerebrovascular [PDF]

, 2021
Introducción: La enfermedad cerebrovascular es el resultado final de un grupo heterogéneo de procesos patológicos que afectan la vasculatura del sistema nervioso, producen isquemia, alteración del metabolismo neuronal y tienen como presentación ...
Quintana Bullain, Arnold, Mendieta Pedroso, Marcel Deniel, Díaz León, Maide   +2 more
core  

Factores de riesgo de ictus. Estudio caso-control en una población de la Comunidad Foral de Navarra

Anales del Sistema Sanitario de Navarra, 2008
Fundamentos. Conocer la prevalencia de diferentes factores de riesgo en los pacientes con enfermedad cerebrovascular de una población de la Comunidad Foral Navarra y compararlo con un grupo control de las mismas características.
A. Hervás
doaj  

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal, Sven J. van der Lee, Melanie Lunding, Lynn Boonkamp, Nolan Barrett, Giulia Monti, Anne Mette G. Jensen, Christian B. Vaegter, Jan Raska, Sona Cesnarikova, Jiri Sedmik, Calvin Trieu, Marjan M. Weiss, Rosalina van Spaendonk, Lisa Vermunt, Georgii Ozhegov, Niccolo Tesi, Marc Hulsman, Dovile Januliene, Arne Moller, Dasa Bohaciakova, Wiesje M. van der Flier, Olav M. Andersen, Charlotte E. Teunissen, Henne Holstege   +24 more
wiley   +1 more source

Factors impacting survival in individuals with Down syndrome‐associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Adults with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), the leading cause of death in this population. Survival in DS after AD diagnosis appears shorter than in sporadic AD; however, the factors influencing survival remain poorly understood.
Bessy Benejam, Mary McCarron, María Carmona‐Iragui, Pamela Dunne, Lucia Maure‐Blesa, Miren Altuna, Javier Arranz, Isabel Barroeta, Alexandre Bejanin, Laura Del Hoyo Soriano, Susana Fernández, Sandra Giménez, Alberto Lleó, Louise Lynch, Philip McCallion, Niamh Mulryan, Lucia Pertierra, Anne‐Sophie Rebillat, Íñigo Rodríguez‐Baz, Aida Sanjuan Hernández, Lídia Vaqué‐Alcázar, Laura Videla, Andrew Wormald, Juan Fortea, Eimear McGlinchey   +24 more
wiley   +1 more source

Factores de riesgo de la enfermedad cerebrovascular en ancianos pertenecientes al Policlínico Universitario Milanés. Matanzas. 2007-2008 Risk factors of cerebrovascular disease in elder people belonging to University Policlinic Milanés. Matanzas. 2007-2008

Revista Médica Electrónica, 2011
Se realizó un estudio observacional, prospectivo y descriptivo, con el objetivo de caracterizar el comportamiento de la enfermedad cerebrovascular de la población anciana, perteneciente a tres consultorios del Equipo Básico # 3, del Policlínico ...
Damarys Hernández Suárez, Alicia Vázquez López, Dalmara Hernández Suárez, Odalys Sánchez Jiménez   +3 more
doaj  

Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline.
Alejandra O. Morcillo‐Nieto, Mateus Rozalem‐Aranha, Lucia Maure‐Blesa, Íñigo Rodríguez‐Baz, José Enrique Arriola‐Infante, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, Lídia Vaqué‐Alcázar, José Allende Parra, Zili Zhao, Javier Arranz, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +24 more
wiley   +1 more source