Results 31 to 40 of about 2,207 (165)

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante, Lídia Vaqué‐Alcázar, Mateus Rozalem‐Aranha, José Allende Parra, Zili Zhao, Javier Arranz, Íñigo Rodríguez‐Baz, Lucia Maure‐Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Miguel Santos‐Santos, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +27 more
wiley   +1 more source

In vivo mapping of cortical amyloid beta‐myelin coupling in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Accumulating evidence suggests that amyloid‐β (Aβ) preferentially deposits in poorly myelinated cortical regions and may interfere with remyelination. We hypothesized that this vulnerability would manifest as altered Aβ–myelin coupling in preclinical Alzheimer's disease (AD).
Mercedes Atienza, Jose L. Cantero
wiley   +1 more source

Factores de riesgo de la enfermedad cerebrovascular en ancianos pertenecientes al Policlínico Universitario Milanés. Matanzas. 2007-2008 Risk factors of cerebrovascular disease in elder people belonging to University Policlinic Milanés. Matanzas. 2007-2008

Revista Médica Electrónica, 2011
Se realizó un estudio observacional, prospectivo y descriptivo, con el objetivo de caracterizar el comportamiento de la enfermedad cerebrovascular de la población anciana, perteneciente a tres consultorios del Equipo Básico # 3, del Policlínico ...
Damarys Hernández Suárez, Alicia Vázquez López, Dalmara Hernández Suárez, Odalys Sánchez Jiménez   +3 more
doaj  

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal, Sven J. van der Lee, Melanie Lunding, Lynn Boonkamp, Nolan Barrett, Giulia Monti, Anne Mette G. Jensen, Christian B. Vaegter, Jan Raska, Sona Cesnarikova, Jiri Sedmik, Calvin Trieu, Marjan M. Weiss, Rosalina van Spaendonk, Lisa Vermunt, Georgii Ozhegov, Niccolo Tesi, Marc Hulsman, Dovile Januliene, Arne Moller, Dasa Bohaciakova, Wiesje M. van der Flier, Olav M. Andersen, Charlotte E. Teunissen, Henne Holstege   +24 more
wiley   +1 more source

Factors impacting survival in individuals with Down syndrome‐associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Adults with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), the leading cause of death in this population. Survival in DS after AD diagnosis appears shorter than in sporadic AD; however, the factors influencing survival remain poorly understood.
Bessy Benejam, Mary McCarron, María Carmona‐Iragui, Pamela Dunne, Lucia Maure‐Blesa, Miren Altuna, Javier Arranz, Isabel Barroeta, Alexandre Bejanin, Laura Del Hoyo Soriano, Susana Fernández, Sandra Giménez, Alberto Lleó, Louise Lynch, Philip McCallion, Niamh Mulryan, Lucia Pertierra, Anne‐Sophie Rebillat, Íñigo Rodríguez‐Baz, Aida Sanjuan Hernández, Lídia Vaqué‐Alcázar, Laura Videla, Andrew Wormald, Juan Fortea, Eimear McGlinchey   +24 more
wiley   +1 more source

Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline.
Alejandra O. Morcillo‐Nieto, Mateus Rozalem‐Aranha, Lucia Maure‐Blesa, Íñigo Rodríguez‐Baz, José Enrique Arriola‐Infante, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, Lídia Vaqué‐Alcázar, José Allende Parra, Zili Zhao, Javier Arranz, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +24 more
wiley   +1 more source

Nivel de conocimientos sobre la enfermedad cerebrovascular en médicos de la atención primaria de salud

Medimay, 2014
Introducción: la enfermedad cerebrovascular, provoca la muerte al individuo, cuando aún, es socialmente activo. El conocimiento médico sobre el manejo de esta entidad, es esencial para lograr la disminución de la morbimortalidad que influye directamente ...
Marcel Mendieta Pedroso, Richard Sera Blanco, Renán Hernández Nuñez, Yeny Hernández Regueiro   +3 more
doaj   +4 more sources

Mortalidad en Colombia por enfermedad cerebrovascular en comparación con enfermedad isquémica coronaria: 1995-2020

Revista Colombiana de Cardiología
Introducción: Con la transición demográfica y el aumento de la población mundial, el número de muertes por enfermedad isquémica cardiaca (EIC) y enfermedad cerebrovascular (ECV) ha ido en aumento en la última década.
María C. Valencia-Mendoza, Camilo Romero, Nicolás Molano-González   +2 more
doaj   +1 more source

Perceptions of Exposure to Neuroendovascular Intervention During Neurology Training in LATAM: An International Multicenter Exploratory Survey and Review of the Literature

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Aim The aim is to assess the exposure to neuroendovascular intervention and perceptions among trainees in Latin America. Methods A descriptive and cross‐sectional study was conducted from October to December 2024 and was aimed at neurology residents and/or fellows in Latin American hospitals.
Miguel A. Vences, Rodrigo Dècima, Virgilio E. Failoc- Rojas, Joel M. Sequeiros, Ankit Dhoundiyal   +4 more
wiley   +1 more source

Enfermedad cerebrovascular y trombofilia

Revista chilena de neuro-psiquiatría, 2002
La trombofilia es una condicion que se debe tener presente en las enfermedades cerebrovasculares (ECV) isquemicas. Si bien se considera que es la causa de un bajo porcentaje de ellas, dada la alta incidencia de las ECV isquemicas, el numero de pacientes con esta condicion pasa a ser significativo.
openaire   +2 more sources