Results 41 to 50 of about 19,892 (218)
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
Nature Communications, 2021 Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent ...
Andrea de la Fuente-Alonso +20 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Cardiovascular diseases (CVDs) are the first cause of death worldwide. In recent years, there has been great interest in the analysis of extracellular vesicles (EVs), including exosomes and microparticles, as potential mediators of biological ...
Jose Luis Martin-Ventura +7 more
doaj +1 more source
“White and Clear” (WaC): A tunable hydrophilic tissue clearing strategy for multi‐species 3D imaging
VIEW, EarlyView.Optical tissue clearing methods help scientists make tissues transparent to image structures deep inside organs in 3D, but many existing techniques are limited in performance and difficulty. In this study, we developed an optimized clearing method called WaC (White and Clear), which improves upon existing techniques by combining efficient tissue ...
Vicente Llorente +12 more
wiley +1 more source
FACTORES DE RIESGO CARDIOVASCULAR
Ciencia & Salud, 2020 Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial, cada año mueren más personas por enfermedades cardiovasculares que por cualquier otra causa de muerte. En Costa Rica, las enfermedades cardiovasculares constituyen una de
Daniel Chevez Elizondo
doaj +1 more source
Enfermedad cardiovascular y obesidad
Revista Vive, 2018 Introducción: Las enfermedades cardiovasculares constituyen la principal causa de muerte a nivel mundial y en conjunto con la obesidad, tienen gran impacto en la salud pública. Objetivo. Relacionar las enfermedades cardiovasculares y la obesidad, en pacientes que acuden a la consulta de cardiología Valencia/Venezuela, en el. Materiales y Métodos.
Darío Saturno +5 more
openaire +2 more sources
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
Enfermedad cardiovascular aterosclerótica y sexualidad
Revista Urología Colombiana / Colombian Urology Journal, 2022 ResumenLa enfermedad cardiovascular aterosclerótica es la primera causa de muerte en todo el mundo, y la principal causa de años de vida perdidos por discapacidad (AVADs) en los adultos. Sus factores de riesgo son muy prevalentes en la población, y su ocurrencia se ha asociado con disfunción sexual tanto en hombres como en mujeres, debido a que ...
Sebastián Galvis-Acevedo +3 more
openaire +1 more source
Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero +7 more
wiley +1 more source
Enfermedad cardiovascular y diabetes
Revista de la Sociedad Argentina de Diabetes, 2020 Según la Organización Mundial de la Salud (OMS), de los 57 millones de muertes globales/año, en el mundo, el 71% se debe a enfermedades no transmisibles y, dentro de ellas, más de la mitad a enfermedad cardiovascular. La hipertensión, el tabaquismo, la glucemia alta, la inactividad física, el sobrepeso y la obesidad, y los niveles altos de colesterol ...
openaire +2 more sources
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral +13 more
wiley +1 more source