Results 51 to 60 of about 488,003 (314)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

GNTI: Gaussian noise-based trajectory imputation via self-supervised learning

Journal of Highway and Transportation Research and Development
Trajectory imputation aims to reconstruct complete movement sequences from noisy or incomplete GPS data, crucial for intelligent transportation systems (ITS).
Siqi Liu, Penghao Zhao, Lei Dong, Na Dong, Liyuan Ding, Guangshi Pei   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Enforcing the GDPR

ISSN:0302 ...
François Hublet, David A. Basin, Srdan Krstic   +2 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Offender residence locations: exploring the impact of spatial scale on variability and concentration

Journal of Spatial Information Science
In recent decades, the analysis of different geographic scales for studying the spatial patterning of crime has profoundly deepened our theoretical grasp of crime dynamics.
Monsuru Adepeju, Samuel Langton, Wouter Steenbeek   +2 more
doaj   +1 more source

Booze, Bars, and Bystander Behavior: People who Consumed Alcohol Help Faster in the Presence of Others.

Frontiers in Psychology, 2016
People help each other less often and less quickly when bystanders are present. In this paper, we propose that alcohol consumption could attenuate or reverse this so-called bystander effect.
Marco eVan Bommel, Marco eVan Bommel, Jan-Willem eVan Prooijen, Henk eElffers, Paul evan Lange   +4 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

The topology of cyberspace and cybercrime journeys: a framework for analyzing online offender mobility

Crime Science
Purpose This paper introduces a novel framework for analyzing online offender mobility. Methods Drawing on multidisciplinary insights, we extend two established criminological models for studying offline offending—the geometry of crime and crime journeys—
Asier Moneva, Stijn Ruiter, Wim Bernasco
doaj   +1 more source