Results 61 to 70 of about 1,219,757 (285)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2022 We aim to push forward the agenda of the University as a part of an ecosystem of knowledge production addressing public problem-solving. With this framework in mind, addressing the concept of Engaged Learning at an early stage (such as the PhD level) has
Klima, NoelRE230000606971428020003526700000-0003-3911-3654FA521F40-F0ED-11E1-A9DE-61C894A0A6B4 +2 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
ENGAGE-DEM : a model of engagement of people with dementia
, 2023 Dementia is a neurodegenerative disease that affects cognition, producing a reduction in thinking, problem-solving, and mnemonic abilities, functioning, preventing affected people to care for themselves and carry out activities of daily living (e.g., self-feeding, dress oneself), and psychosocial well-being, causing the appearance of disorders of ...
openaire +4 more sources
Engaged Scholarship in the Context of Housing Insecurity and the Built Environment
In this issue, Wanda Martin, Kerry McPhedran, Shelley Kirychuk, and Lori Bradford, ESJ’s editor-in-chief, explores the concept of engaged scholarship within the realm of housing insecurity and the built environment.
Bradford, Lori +3 more
core +1 more source
Digesting detention: how to document eating patterns in jail
BMC NutritionBackground People incarcerated experience significant health inequities compared to the non-incarcerated population, including higher rates of many diet-related diseases.
Elizabeth Schmitter +6 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Canadian Engaged Scholarship and the Russian War against Ukraine [PDF]
ESJ’s managing editor Penelope Sanz converses with Dr. Natalia Khanenko-Friesen, director of the Canadian Institute of Ukrainian Studies (CUIS) at University of Alberta, about engaged scholarship in the context of the Ukraine-Russia war.
Sanz, Penelope C +1 more
core
Politically engaged artistic practice: Strategies and tactics [PDF]
, 2020 This paper explores political forms of artistic practice operating within Tate Exchange broadly and within the authors’ creative practice specifically. It identifies the tensions and obstacles inherent to socially engaged artistic practice and forms of ...
Sharkey, T., Bates, D.
core