Results 51 to 60 of about 1,440 (137)

Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Nitric oxide (NO) production is regulated by a plethora of upstream mediators, including glutamate, serotonin, and inflammatory mediators, at both neurons and non‐neuronal cells. These mediators are regulated by stressors, and their activity can increase or decrease NO production in a nitric oxide synthase (NOS) isoform‐dependent way.
João Alphonse Apóstolo Heymbeeck, Eveline Bezerra de Sousa, Monica Lima‐Maximino, Antonio Pereira Jr., Caio Maximino   +4 more
wiley   +1 more source

Validation of CBCL depression scores of adolescents in three independent datasets

JCPP Advances, Volume 5, Issue 3, September 2025.
Depression is common, burdensome, and is frequently first diagnosed in adolescents, thus the popular Adolescent Brain Cognitive Development dataset (ABCD) provides an attractive opportunity to research depression in adolescents. The only DSM‐5‐oriented continuous measure of depression in ABCD is the parent‐report Child Behavior Checklist's DSM‐5 ...
Marie Zelenina, Daniel S. Pine, Argyris Stringaris, Dylan M. Nielson   +3 more
wiley   +1 more source

Melanoma in the Eyes of Mechanobiology

Frontiers in Cell and Developmental Biology, 2020
Skin is the largest organ of the human body with several important functions that can be impaired by injury, genetic or chronic diseases. Among all skin diseases, melanoma is one of the most severe, which can lead to death, due to metastization ...
M. Manuela Brás, M. Manuela Brás, M. Manuela Brás, Manfred Radmacher, Susana R. Sousa, Susana R. Sousa, Susana R. Sousa, Pedro L. Granja, Pedro L. Granja, Pedro L. Granja   +9 more
doaj   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, Volume 14, Issue 15, 10 June, 2025.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof‐of‐Concept Study

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
Helicobacter pylori gastric infection is widespread and recurrency is common, fuelled by bacterial resistance to antibiotics. Therefore, specific and noninducing resistance alternative treatments are an urgent need. Taking advantage of this gastric pathogen auxotrophy for cholesterol, a “trojan horse” strategy for H.
Ana Sofia Pinho, Renato Pereira, Mariana Pereira, Akhilesh Rai, Lino Ferreira, Maria Cristina Lopes Martins, Paula Parreira   +6 more
wiley   +1 more source

Characterization of clinical patterns of dengue patients using an unsupervised machine learning approach

BMC Infectious Diseases, 2019
Background Despite the greater sensitivity of the new dengue clinical classification proposed by the World Health Organization (WHO) in 2009, there is a need for a better definition of warning signs and clinical progression of dengue cases.
Gleicy Macedo Hair, Flávio Fonseca Nobre, Patrícia Brasil   +2 more
doaj   +1 more source

Neuro‐Immunomodulatory Potential of Nanoenabled 4D Bioprinted Microtissue for Cartilage Tissue Engineering

Advanced Healthcare Materials, Volume 14, Issue 5, February 18, 2025.
4D‐bioprinted HCM nanoenabled with ibuprofen‐PLGA nanoparticles is presented. In an in vitro inflamed environment, nanoenabled HCM reduced IL‐1β and IL‐6 release and maintained ECM production, and in vivo, its secretome reduced dendritic cell recruitment, and inflammatory mediators, with no impact on nerve sprouting, indicating neuro‐immunomodulatory ...
Marina Couto, Daniela Pereira Vasconcelos, Catarina Leite Pereira, Estrela Neto, Bruno Sarmento, Meriem Lamghari   +5 more
wiley   +1 more source

Embedding Bioprinting of Low Viscous, Photopolymerizable Blood‐Based Bioinks in a Crystal Self‐Healing Transparent Supporting Bath

Small Methods, Volume 9, Issue 1, January 20, 2025.
Crystal self‐healing embedding bioprinting (CLADDING) enables the use of low viscosity protein‐based hydrogels as bioinks. By printing liquid bioinks within a transparent, self‐healing support bath governed by complex coacervation, CLADDING allows for the creation of stable, high‐density cellular constructs with excellent viability.
Monize Caiado Decarli, Helena P. Ferreira, Rita Sobreiro‐Almeida, Filipa C. Teixeira, Tiago R. Correia, Joanna Babilotte, Jos Olijve, Catarina A. Custódio, Inês C. Gonçalves, Carlos Mota, João F. Mano, Lorenzo Moroni   +11 more
wiley   +1 more source

Artificial intelligence on breast cancer risk prediction

Societal Impacts
Breast Cancer is currently the most commonly diagnosed type of cancer worldwide. While the impacts of this disease can be mitigated through early diagnosis, generalized screening programs based on full-field digital mammography present several ...
João Mendes, Bernardo Oliveira, Carolina Araújo, Joana Galrão, Nuno C. Garcia, Nuno Matela   +5 more
doaj   +1 more source

Futebol: o estado do conhecimento das dissertações e teses nas engenharias

Revista Brasileira de Futsal e Futebol, 2021
Com objetivo de investigar o estado do conhecimento das dissertações e teses produzidas no Brasil sobre temática futebol nas Engenharias de 1989 a 2018, a pesquisa buscou, recuperou e preparou os dados, dando-lhes tratamento estatí­stico, representação ...
Alex Fensterseifer
doaj