Results 111 to 120 of about 2,795,262 (398)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Development of a Dragonfly-Inspired High Aerodynamic Force Flapping-Wing Mechanism Using Asymmetric Wing Flapping Motion

Biomimetics
Bionic micro air vehicles are currently being popularized for military as well as civilian use and dragonflies display a wealth of skill in their remarkable flight capabilities.
Jinze Liang, Mengzong Zheng, Tianyu Pan, Guanting Su, Yuanjun Deng, Mengda Cao, Qiushi Li   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Investigation on Flow Characteristics and Parameters Optimization of a New Concept of TC Nozzle

Journal of Applied Fluid Mechanics, 2021
Lighter weight, simpler structure and throat area controllable are the developing trends of aircraft engine exhaust system. To meet these challenges, a new concept of hybrid throat control (TC) nozzle was proposed to improve the control efficiency of ...
F. Song, L. Zhou, J. W,. Shi, Z. X. Wang
doaj  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Thermal Characteristics Investigation of the Internal Combustion Engine Cooling-Combustion System Using Thermal Boundary Dynamic Coupling Method and Experimental Verification

Energies, 2018
The engine cooling system must be able to match up with the stable operating conditions so as to guarantee the engine performance. On the working cycle level, however, the dynamic thermo-state of engines has not been considered in the cooling strategy ...
Junhong Zhang, Zhexuan Xu, Jiewei Lin, Zefeng Lin, Jingchao Wang, Tianshu Xu   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Improvements in petrol engine performance with ultrasonic fuel atomisation [PDF]

, 1966
Initial studies of the effect of air-fuel mixture preparation on piston engine performance have been conducted on a four cylinder 1600 cc petrol engine using conventional carburation and ultrasonic fuel atomisation.
Norster, E. R.
core  

Compensating cooling on the suction surface of the blade by the jets of the film holes on the endwall

Case Studies in Thermal Engineering
The coolant ejected from the film holes on the gill region of the blade deflects to the blade tip in the action of the cascade passage vortices, resulting in the local film cooling failure on the suction surface near the endwall. This paper introduces an
Changyu Zhao, Junyu Zhu, Wei Zhang, Zhiqi Zhao, Guangchao Li, Chun Li   +5 more
doaj   +1 more source