Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis +4 more
wiley +1 more source
Physical and Biomechanical Relationships with Countermovement Jump Performance in Team Sports: Implications for Athletic Development and Injury Risk. [PDF]
Bygate-Smith MK, Beaven CM, Drury M.
europepmc +1 more source
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Real-Time Visual Anomaly Detection in High-Speed Motorsport: An Entropy-Driven Hybrid Retrieval- and Cache-Augmented Architecture. [PDF]
Cádiz RJ, Rodríguez-Sela F.
europepmc +1 more source
Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge +9 more
wiley +1 more source
Review of State Estimation Methods for Autonomous Ground Vehicles: Perspectives on Estimation Objects, Vehicle Characteristics, and Key Algorithms. [PDF]
Wang X, Chen T, Wang R, Lu J, Dou G.
europepmc +1 more source
Dynamic road section risk identification model based on connected in-vehicle data. [PDF]
Zhang Y, Yang G, Xie T.
europepmc +1 more source
Effect of adaptive cruise control on fuel consumption in real-world driving conditions. [PDF]
Moawad A +5 more
europepmc +1 more source
Numerical study on the forward and inverse problems of the mobile pump truck frame. [PDF]
Zhang YL, Lin HB, Zhu ZC.
europepmc +1 more source

