Results 101 to 110 of about 14,893 (308)

Numerical Simulation for Engine/Airframe Interaction Effects of the BWB300 on Aerodynamic Performances

International Journal of Aerospace Engineering, 2019
The engine/airframe interaction effects of the BWB300 on aerodynamic performances were analyzed by using the numerical simulation method. The BWB300 is a 300-seat Blended Wing Body airplane designed by the Airplane Concept Design Institute of ...
Gang Yu, Dong Li, Yue Shu, Zeyu Zhang
doaj   +1 more source

Combustion Analysis of a CI Engine with Biodiesel Blends based on Vibro-Acoustic Measurement

In this paper, a combustion analysis of a compression ignition (CI) engine operating with biodiesel blends has been experimentally investigated to examine the effects of biodiesel on the combustion process and the characteristics of the engine noise ...
Gu, Fengshou, Ball, Andrew, Zhen, Dong, Tran, Van Tung, Wang, T.   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimental assessing of the performances of a MILD-based Stirling engine fed with LCV gas

, 2016
In the field of energy production, cogeneration systems based on Stirling cycles appear particularly suitable to reach the goals of improving efficiency and reducing pollutants, as they ensure high efficiency, fuel flexibility, low emissions, low noise ...
Sampath, Rangakishen Mavanour, Magnusson, Alf,, Jog, Priyanka, Parente, Alessandro, Abou-Taouk, Abdallah,, Wettrell, Pontus, Fortunato, Valentina   +6 more
core  

CFD parametric analysis of the combustion chamber shape in a small HSDI Diesel engine

, 2005
The paper aims at providing information about the influence of the combustion chamber shape on the combustion process evolution in a high speed direct injection (HSDI) small unit displacement engine for off-highway applications. Small HSDI Diesel engines
Stefano Fontanesi, MATTARELLI, Enrico, GAGLIARDI, Vincenzo, MALAGUTI, Simone, Vincenzo Gagliardi, Enrico Mattarelli, Simone Malaguti, FONTANESI, Stefano   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Propulsion aéronautique : études expérimentales de la combustion

Comptes Rendus. Mécanique
Apart from light aviation, the majority of aeronautical propulsion relies on the implementation of turbomachinery, whose energy and environmental performances are continuously improving.
Vincent-Randonnier, Axel
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modelling and Experimental Validation of a VNT Turbocharger for Improving Performances of a Marine Diesel Generator Engine

, 2020
This paper presents modelling and experimental validation for improving the performances of a marine diesel generator engine. Based on the diesel engine theory, thelaws of conservation of energy, and the principle of movement of flow through turbocharger
Duong, Bui Hong, Vang, Le Van, Le Van Vang, Vinh, Nguyen Quang, Bui Hong Duong, Nguyen Quang Vinh   +5 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source