Results 81 to 90 of about 14,893 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Performances of methane-powered crawler tractor tested in stationary and field conditions

Energy Conversion and Management: X
Nowadays, global attention is focused on the production and use of renewable energy to combat climate change and achieve energy independence. In this context, the agricultural sector plays a key role by utilizing biogas-upgrading systems from anaerobic ...
D. Assandri, E. Cavallo, M. Tamagnone, N. Pampuro   +3 more
doaj   +1 more source

INVESTIGATION OF THE EFFECT OF AIR HUMIDITY ON GAS TURBINE ENGINE PARAMETERS

Авіаційно-космічна техніка та технологія, 2017
The mathematical model of a turbo-shaft engine with a two-stage gas generator was obtained. This model is based on the multi-stage compressor blade – to - blade description, which makes it possible to evaluate the effect of air humidity on its ...
Людмила Георгиевна Бойко, Вадим Анатольевич Даценко   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A New Hydraulic Variable Valve Timing and Lift System for Spark Ignition Engine

Chemical Engineering Transactions, 2016
A continuous variable valve timing and lift system by hydraulic volume adjustable (CVVTL) for both intake and exhaust valves of Spark Ignition (SI) engine is introduced in this paper.
J.D. Chen, Z.Q. Wang, F.G. Tian
doaj   +1 more source

Jet Engine Performances During Cruise [PDF]

, 2019
Analiza performansi mlaznoga motora u režimu krstarenja sa svrhom opisa uvjeta koji utječu na rad mlaznoga motora, na različitim režimima krstarenja. Za razmatranje problematike funkcioniranja mlaznoga motora na visokim razinama leta, mora se poznavati ...
Cesarec, Ivan
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

VARIATION OF MAIN PARAMETERS OF THE OPERATION OF THE RECIPROCATING ENGINE ACCORDING TO SPEED PERFORMANCES [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2012
Comformity of changing of main parameters at operation of the reciprocating engine with air spool diffuser on two apeed performances was investigated.
Voronkov, A., Nikitchenko, I. , Teslenko, Ye., Minin, A.   +3 more
doaj