Results 41 to 50 of about 84,751 (254)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The safety case for a deep geological repository in Switzerland: engineered barriers for low- and intermediate-level waste disposal

Frontiers in Nuclear Engineering
The safe geological disposal of low- and intermediate-level radioactive waste relies on a passive multi-barrier system. This paper presents the provisional Swiss design for the low- and intermediate-level waste (L/ILW) emplacement caverns and their ...
Lukas Martin, Georg Kosakowski, Typhaine Guillemot, Alexandros Papafotiou   +3 more
doaj   +1 more source

Cyber physical systems: Systems engineering of industrial embedded systems — Barriers, enablers and opportunities [PDF]

2013 International Conference on Compilers, Architecture and Synthesis for Embedded Systems (CASES), 2013
Cyber physical systems: systems engineering of industrial embedded systems-barriers, enablers and opportunities; high-performance, scalable, general-purpose processors to accelerate high-throughput networking and security applications; Low-power high-performance asynchronous processors.
Clas A. Jacobson, Richard Schooler, Michel Laurence   +2 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota

Frontiers in Immunology, 2021
Lactic acid, a metabolic by-product of host and intestinal microbiota, has been recovered as an active signal molecule in the immune system. In this study, a lactic acid biosynthesis pathway that directly produces lactic acid from glucose rather than ...
Siyuan Sun, Xiuxiu Xu, Ling Liang, Xiaoli Wang, Xue Bai, Lanping Zhu, Qijin He, Huixi Liang, Xin Xin, Li Wang, Chenxi Lou, Xiaocang Cao, Xin Chen, Bingzhi Li, Bangmao Wang, Jingwen Zhao   +15 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Thermo-hydro-mechanical evolution of the engineered barrier system of a deep geological repository

Journal of Rock Mechanics and Geotechnical Engineering
This paper investigates the long-term evolution of the engineered barrier system of a deep geological repository (DGR) for used nuclear fuel in Canada, focusing on coupled thermo-hydro-mechanical (THM) processes in bentonite buffer materials.
Uy D. Vo, Mamadou Fall, Julio Á.I. Sedano, Son T. Nguyen   +3 more
doaj   +1 more source

Cover systems with synthetic water‐repellent soils

Vadose Zone Journal, 2021
A cover system is a crucial component of engineered landfills, to minimize water percolation into the underlying waste. Capillary barriers are an alternative cover system, which has been widely used in the arid and semiarid regions as no cohesive, low ...
Shuang Zheng, Xin Xing, Sérgio D. N. Lourenço, Peter J. Cleall   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source