Results 151 to 160 of about 1,132,786 (309)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Directions in mechanical engineering
Journal of King Saud University: Engineering Sciences, 2014 Richard M. Lueptow
doaj +1 more source
Biomimetics as a Functional Engineering Framework for Mechanical Systems: A PRISMA-Guided Systematic Mapping of Sensing, Inspection, Access Robotics, and Condition Monitoring (2016-2026). [PDF]
Biomimetics (Basel)Ketterer CG, Ortega NN, Valín JL.
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Scalability of carbon-neutral cooling system
, 2019 Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from the official PDF of thesis.Includes bibliographical references (page 26).The scalability of a carbon neutral cooling system to provide the MIT ...
Noh, Christine (Researcher in mechanical engineering).
core
MECHANICAL & ELECTRICAL ENGINEERING TECHNOLOGY
Jixie chuandong, 2015 <正>《机电工程技术》杂志创刊于1971年,为国际大16开本（210mm×285mm）,全彩+黑白印刷,月刊（每月20日出版）,国内外公开发行,在制造业影响大、读者面广,由广东省机械研究所、广东省机械技术情报站和广东省机械工程学会联合主办。本刊是经过国家科技部、国家新闻出版总署批准出版的大型综合性机电期刊,专注报道机电工业领域的行业动态、先进技术、市场趋势及供求信息,面向机电产品企业高级管理人员、生产设计部门技术人员、产品和市场部经理,
doaj
Enhancing mechanical performance of sandwich structures via uniform and gradient auxetic cores. [PDF]
Sci RepTaha HW +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source