Results 41 to 50 of about 11,748,761 (306)

Collaborative Engineering Environments. Two Examples of Process Improvement [PDF]

, 1998
Companies are recognising that innovative processes are determining factors in competitiveness. Two examples from projects in aircraft development describe the introduction of collaborative engineering environments as a way to improve engineering ...
Bijwaard, D.J.A., Laan, D.J., Spee, J.B.R.M.   +2 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Knowledge Engineering for Non-engineers [PDF]

, 2010
This paper presents one approach for the innovative organization training for business analysts in developing enterprise ontologies. The underlying teaching framework is pursuing a methodology that will aid the process of knowledge structuring and practical ontology design, with emphasis on visual techniques.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Bacterial Stress Responses To 1-Megahertz Pulsed Ultrasound In The Presence Of Microbubbles [PDF]

, 1998
Members of a panel of stress-responsive biosensors have been used to study the effect of megahertz frequency ultrasound onEscherichia coli. Insonification causes acoustic cavitation, the collapse of oscillating microbubbles in solution, which can damage ...
Everbach, E. Carr, Halpern, Matthew Evan, , \u2798, Kwakye, Sylvia D. Sakyiama, , \u2798, Vollmer, Amy Cheng   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Engineering Feasibility Study of Fire Island as a Location for a Future Correctional Facility: Final Report [PDF]

, 1986
The "Legal Factors" section appearing on page 38–50 of this report was prepared by Stephen Conn of the UAA Justice Center, School of Justice. / This report is part of the Fire Island Prison Feasibility Study, a project conducted jointly by the School
Junge, David C., UAA School of Engineering   +1 more
core  

Three-Dimensional Phase Step Profilometry With A Multicore Optical Fiber [PDF]

, 2012
This paper demonstrates the feasibility of using phase stepping and a multicore optical fiber to calculate an object\u27s depth profile. An interference pattern is projected by an optical fiber onto the object.
D\u27Annunzio, David Joseph, , \u2712, Inci, N., Molter, Lynne, , \u2779, Novack, Ari Jason, , \u2712, Çubuk, Ekin Dogus, , \u2710   +4 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source