Results 41 to 50 of about 13,015,703 (339)

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Managing design variety, process variety and engineering change: a case study of two capital good firms [PDF]

open access: yes, 2012
Many capital good firms deliver products that are not strictly one-off, but instead share a certain degree of similarity with other deliveries. In the delivery of the product, they aim to balance stability and variety in their product design and ...
Alblas, A., Veldman, J.
core   +5 more sources

Modern Control Engineering

open access: yes, 2001
Introduction to automatic control systems mathematical background mathematical models of systems classical time-domain analysis of control systems state-space analysis of control systems stability the root locus method frequency domain analysis classical
P. Paraskevopoulos
semanticscholar   +1 more source

Learning requirements engineering within an engineering ethos [PDF]

open access: yes, 2004
An interest in educating software developers within an engineering ethos may not align well with the characteristics of the discipline, nor address the underlying concerns of software practitioners.
Armarego, J.
core   +1 more source

Finite element procedures in engineering analysis

open access: yes, 1982
Keywords: Methode des elements finis ; Mathematique ; Elements finis Reference Record created on 2004-09-07, modified on 2016-08 ...
K. Bathe, H. Saunders
semanticscholar   +1 more source

Systematic Mapping Studies in Software Engineering

open access: yesInternational Conference on Evaluation & Assessment in Software Engineering, 2008
BACKGROUND: A software engineering systematic map is a defined method to build a classification scheme and structure a software engineering field of interest. The analysis of results focuses on frequencies of publications for categories within the scheme.
K. Petersen   +3 more
semanticscholar   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

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