Results 51 to 60 of about 11,364,271 (247)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Public Perceptions of the Midwest’s Pavements - Wisconsin - Phase I (Winter Ride) [PDF]
, 2001 The Wisconsin Winter Ride Survey was designed to determine the extent to which drivers were tolerant of the rougher ride of pavements on rural two-lane highways in the winter.
Marquette University,Department of Civil, Construction, and Environmental Engineering
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Unraveling the origin of ferroelectric resistance switching through the interfacial engineering of layered ferroelectric-metal junctions [PDF]
, 2021 Fei Xue +8 more
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Aspects of the Requirements of ISO 15263.4 and the Design and Development of Bicycle Racks [PDF]
There is currently interest in developing safety standards for bicycle racks for cars. A draft international standard (ISO 15263.4) has been developed. However, there have been many objections to the proposals and a redraft has been made.
Pendle Engineering, Robson, Martin
core
Engineering at San Jose State University, Spring 2018 [PDF]
, 2018 https://scholarworks.sjsu.edu/engr_news/1017/thumbnail ...
San Jose State University, Charles W. Davidson College of Engineering
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Engineering at San Jose State University, Spring 2006 [PDF]
, 2006 https://scholarworks.sjsu.edu/engr_news/1003/thumbnail ...
San Jose State University, Charles W. Davidson College of Engineering
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source