Results 81 to 90 of about 11,364,271 (247)

3D micromesh-based hybrid bioprinting: multidimensional liquid patterning for 3D microtissue engineering [PDF]

, 2022
Byungjun Lee, Suryong Kim, Jihoon Ko, Byungjun Lee, Youngtaek Kim, Seonghyuk Park, Jiho Kim, Sujin Hyung, Ho‐Young Kim, Noo Li Jeon   +9 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A global database and “state of the field” review of research into ecosystem engineering by land animals [PDF]

, 2018
Nicole Coggan, Matt W. Hayward, Heloise Gibb   +2 more
openalex   +1 more source

Microbial production of small peptide: pathway engineering and synthetic biology [PDF]

, 2021
Zhiyong Wu, Youran Li, Liang Zhang, Zhongyang Ding, Guiyang Shi   +4 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Photothermal Catalyst Engineering: Hydrogenation of Gaseous CO₂ with High Activity and Tailored Selectivity [PDF]

, 2017
Jia Jia, Hong Wang, Zhuole Lu, Paul G. O’Brien, Mireille Ghoussoub, Paul N. Duchesne, Ziqi Zheng, Peicheng Li, Qiao Qiao, Lu Wang, Alan Gu, Feysal M. Ali, Yuchan Dong, Qiang Wang, Kulbir Kaur Ghuman, Thomas E. Wood, Chenxi Qian, Yue Shao, Chenyue Qiu, Miaomiao Ye, Yimei Zhu, Zheng‐Hong Lu, Peng Zhang, Amr S. Helmy, Chandra Veer Singh, Nazir P. Kherani, Doug D. Perovic, Geoffrey A. Ozin   +27 more
openalex   +1 more source

Rational engineering of natural polyhydroxyalkanoates producing microorganisms for improved synthesis and recovery [PDF]

, 2022
José Manuel Borrero‐de Acuña, Ignacio Poblete‐Castro   +1 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Maximizing information from chemical engineering data sets: Applications to machine learning

, 2022
Alexander Thebelt, Johannes Wiebe, Jan Kronqvist, Calvin Tsay, Ruth Misener   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source