Results 131 to 140 of about 3,277 (223)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Investigation of the machining processes of flexible fibrous materials for applications in industrial automation. [PDF]

, 1992
Saadat-Sarmadi, Mozafar
core  

Enhancement of modern defense capabilities by convergence of cognitive neuroscience and artificial intelligence. [PDF]

Front Psychol
Cosic K, Kuljanac A, Palermo S.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Establishing a global medical physics graduate clinical training and development program in Ghana: A model for global health international education and collaboration. [PDF]

J Appl Clin Med Phys
O'Reilly SE, Avery S, Dinh L, Friberg A, Okuribido A, Addison EK, Inkoom S, Baidoo AM, Tagoe SN, Kaufmann EE, Gwak S, Doherty ML, Sosu E, Addai BW, Hasford F.   +14 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sampling design and estimation procedure for energy audit and carbon footprints for onion crop in India. [PDF]

Sci Rep
Aditya K, Bharti, Das P, Banerjee R, Rathinakumari AC, Ahmad T, Bhargav VK, Kumaran GS, Venu SA.   +8 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

FORECASTING FUTURE EMPLOYMENT OPPORTUNITIES FOR FOOD, AGRICULTURE, AND NATURAL RESOURCES HIGHER EDUCATION GRADUATES USING ADJUSTED BUREAU OF LABOR FORECASTS

Forecasts of the number of future professionals required for an ongoing safe, efficient US food system are highly important. The demand for adequately prepared higher education graduates must be met by the US Food, Agriculture, and Natural Resources ...
Litzenberg, Kerry K., Bullock, K. Wayne
core  

Hybrid CNN-GCN framework for brain tumor MRI classification: A graph-based approach to smart healthcare diagnostics. [PDF]

J Appl Clin Med Phys
Alkasasbeh MS, Ibnaouf KH, Ahmed NM, Rahman AA, Abbas DN, Al Tawil A, Idriss H, Alkasasbeh HT.   +7 more
europepmc   +1 more source