Results 131 to 140 of about 112,379 (218)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Polycyclic aromatic hydrocarbon exposure in battlefield and beyond: Implications for environmental- and human health. [PDF]

Toxicol Rep
Hamilton MD, Chauhan R, Archibong AE, Ramesh A.   +3 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Development of a tool to enhance street cleaning service efficiency: The case study of Porto city, Portugal. [PDF]

Waste Manag Res
Guedes M, Pires JCM, Martins FG, Lucas CS, Claro H, Pereira MFR, Dias JM.   +6 more
europepmc   +1 more source

Schenectady, City of and Trade Unions, International Brotherhood of Painters and Allied Trades (PAT), International Brotherhood of Carpenters and Joiners (IBCJ) Local 370, International Union of Bricklayers and Allied Craftsmen (BAC) Local 2, United Association of Journeymen and Apprentices of the Plumbing and Pipefitting Industry (PPF) Local 7 (2000) [PDF]

, 2000

core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

A large-scale reconfigurable multiplexed quantum photonic network. [PDF]

Nat Photonics
Valencia NH, Ma A, Goel S, Leedumrongwatthanakun S, Graffitti F, Fedrizzi A, McCutcheon W, Malik M.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Automated Malaria Ring Form Classification in Blood Smear Images Using Ensemble Parallel Neural Networks. [PDF]

J Imaging
Pongpanitanont P, Suttidate N, Nuinoon M, Khampeeramao N, Laymanivong S, Janwan P.   +5 more
europepmc   +1 more source

Canada’s First Armoured Unit: Raymond Brutinel and the Canadian Motor Machine Gun Brigades of the First World War [PDF]

, 2012
Pulsifer, Cameron
core   +1 more source