Results 151 to 160 of about 5,939,495 (207)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Occupational Zoonotic Risk at India's Human-Animal Interface: Statutory Origins and a Regulatory Pathway for the Compensation-Prevention Disconnect. [PDF]

Am J Ind Med
Bhatt LK.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Bridging the governance gap in health artificial intelligence: integrating nursing perspectives into the National Academy of Medicine Artificial Intelligence Code of Conduct. [PDF]

J Am Med Inform Assoc
Cary MP, Russell RG, Silcox C, Lytle KS, Lehmann LS, Hightower M, Economou-Zavlanos N, Guilamo-Ramos V.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Establishing a global medical physics graduate clinical training and development program in Ghana: A model for global health international education and collaboration. [PDF]

J Appl Clin Med Phys
O'Reilly SE, Avery S, Dinh L, Friberg A, Okuribido A, Addison EK, Inkoom S, Baidoo AM, Tagoe SN, Kaufmann EE, Gwak S, Doherty ML, Sosu E, Addai BW, Hasford F.   +14 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Cerium oxide and bismuth oxide nanocomposites as clay swelling inhibitors in water based drilling fluids. [PDF]

Discov Nano
Oriquat G, Alrhym BA, Rao ACU, Chaudhary SP, Bains PS, Singh R, Nurshod M, Eshmetov R, Abumalek A.   +8 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Sampling design and estimation procedure for energy audit and carbon footprints for onion crop in India. [PDF]

Sci Rep
Aditya K, Bharti, Das P, Banerjee R, Rathinakumari AC, Ahmad T, Bhargav VK, Kumaran GS, Venu SA.   +8 more
europepmc   +1 more source