Results 41 to 50 of about 3,279 (223)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Soil Sampling at Sword Beach – Luc-Sur-Mer, France, 1943: How Geotechnical Engineering Influenced the D-Day Invasion and Directed the Course of Modern History [PDF]

open access: yes, 2008
This paper presents an historical account of covert soil sampling operations conducted by the British Royal Navy’s No. 1 Combined Operations Pilotage and Beach Reconnaissance Party on December 31, 1943, near Luc-sur-Mer, France at the beach later given ...
Lawson, William D.
core   +1 more source

Liquid-fluidized-bed heat exchanger flow distribution models [PDF]

open access: yes, 1979
Allied Chemical Corporation at the Idaho National Engineering Laboratory is developing liquid-fluidized-bed shell-and-tube heat exchangers for geothermal applications.
Allen, C. A., Cole, L. T.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Implication of FORCEnet on coalition forces [PDF]

open access: yes, 2006
The coalition navies of Australia, Canada, New Zealand, United Kingdom and the United States (AUSCANNZUKUS) are in a period of transformation. They are stepping out of the Industrial Age of warfare and into the Informational Age of warfare.
Jung, Vincent   +10 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Agent-based simulation and analysis of a defensive UAV swarm against an enemy UAV swarm [PDF]

open access: yes, 2011
Unmanned systems, including unmanned combat aerial vehicles (UCAVs), are increasingly important in military operations. Given the growth of unmanned systems technology worldwide, these systems may increasingly pose a real threat to U.S.
Munoz, Mauricio F.
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Rapidly deployable, self forming, wireless networks for maritime interdiction operations [PDF]

open access: yes, 2006
The term "Maritime Interdiction Operations" usually refers to Visit, Board, Search and Seizure (VBSS) operations executed today all over the world. These operations are conducted as a part of the maritime law enforcement policy of each country inside ...
Stavroulakis, Georgios.
core  

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