Results 51 to 60 of about 5,939,495 (207)

A Distributed Knowledge Model for Collaborative Engineering Knowledge Management in Allied Concurrent Engineering

open access: yes, 2010
[[abstract]]The objective of this research is to develop a distributed knowledge model for knowledge management, which is able to support collaborative knowledge management in the practice of allied concurrent engineering.
王昌斌;楊惠媚;陳裕民;陳育仁
core  

Operations instructions no. 60: Allied Air Forces.

open access: yes, 2022
Enclosures/illustrations detail areas of responsibility for air and naval action (dividing lines between Southwest Pacific forces and Pacific Ocean Areas forces) and Far East air forces principal command and liaison channels.
Headquarters, Allied Air Forces, Southwest Pacific Area; Beebe, R. E.
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Operations instructions number 54: Allied Air Forces.

open access: yes, 2022
Annex 1- U.S. Army Air Force units west of 159 degrees east longitude being transferred to Allied Air Forces on 15 June 1944 (unit and strength). Annex 2- U.S.
Headquarters, Allied Air Forces, Southwest Pacific Area; Beebe, R. E.
core  

Modelling production ramp-up of engineering products [PDF]

open access: yes, 2010
Companies that introduce new products quickly have been shown to be better performers. The effectiveness of the new product introduction process is critical to their performance. Production ramp-up is a necessary phase of new product introduction, and
Roberts, S.   +11 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Distributed Knowledge Model for Collaborative Engineering Knowledge Management in Allied Concurrent Engineering

open access: yes, 2015
[[abstract]]The objective of this research is to develop a distributed knowledge model for knowledge management,which is able to support collaborative knowledge management in the practice of allied concurrent engineering.The underlying approach to the ...
陳育仁   +1 more
core  

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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