A Single-Expression Formula for Inverting Strain-Life and Stress-Strain Relationships [PDF]
Starting with the basic fatigue lift formula, an inversion formula is derived. The inversion formula is valid over the entire life range of engineering interest for all materials examined. Conformity between the two equations is extremely close, suitable
Manson, S. S., Muralidharan, U.
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
(Invited) All Solid-State Batteries: Synthesis, Interfacial Engineering and Recycling [PDF]
, 2020 Ying Shirley Meng
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A project based approach to learning for first year engineering students [PDF]
, 2008 Support for transition from Leaving Certificate and entry to college for 1st year engineering students can be difficult to achieve. This new course offers an innovative project based approach to learning for 1st years with an introduction to design to ...
Corcoran, Brian, Whelan, John
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Not All Lies Are Equal. A Study Into the Engineering of Political Misinformation in the 2016 US Presidential Election [PDF]
, 2019 Axel Oehmichen +5 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Argument-driven Engineering in Middle School Science Classrooms: The Study of Engineering Attitudes and Efforts to Broaden Engineering Participation by Exposing All Students to Multiple Engineering Design Tasks (RTP, Diversity) [PDF]
, 2020 Lawrence Chu +6 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source