Results 101 to 110 of about 4,694,604 (252)

Development of a Practical Synthesis of the 8‑FDC Fragment of OPC-167832

ACS Omega, 2022
Vijayagopal Gopalsamuthiram, Dang Binh Ho, Cheryl L. Peck, Vasudevan Natarajan, Toolika Agrawal, Justina M. Burns, John Bachert, Daniel W. Cook, Rodger W. Stringham, Ryan Nelson, Saeed Ahmad, B. Frank Gupton, David R. Snead, D. Tyler McQuade, Rajappa Vaidyanathan, Kai Donsbach, Joshua D. Sieber   +16 more
doaj   +1 more source

Engineering design project : series 2 [PDF]

, 2017
This book is a compilation of engineering design projects which illustrates a detail explanation on the design process including all tools and methods involved in each design stage.

core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Emotion, engineering and ethics [PDF]

, 2008
Adopting Martha Nussbaum's view provides grounds for recognizing those bursts of anger or delight and the responses to them that alter the course of development of engineering projects.
Monk, John
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crystal engineering in all its hues in IUCrJ

IUCrJ, 2020
Gautam R. Desiraju
doaj   +1 more source

Culture dimensions in software development industry: The effects of mentoring [PDF]

, 2011
Software development is a human centric and sociotechnical activity and like all human activities is influenced by cultural factors. However, software engineering is being further affected because of the globalization in software development. As a result,
Casado-Lumbreras, Cristina, Colomo-Palacios, Ricardo, Misra, Sanjay, Soto-Acosta, Pedro   +3 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Homogeneous polymer-ionic solvate electrolyte with weak dipole-dipole interaction enabling long cycling pouch lithium metal battery

Nature Communications
Solid polymer electrolytes (SPEs) are considered as promising electrolytes for high-voltage lithium metal batteries. Whereas, the strong dipole-dipole interaction in polymer electrolytes limits the enhancement of the ionic conductivity.
Likun Chen, Tian Gu, Jinshuo Mi, Yuhang Li, Ke Yang, Jiabin Ma, Xufei An, Yuyuan Jiang, Danfeng Zhang, Xing Cheng, Shaoke Guo, Zhuo Han, Tingzheng Hou, Yidan Cao, Ming Liu, Wei Lv, Yan-Bing He, Feiyu Kang   +17 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source