Results 61 to 70 of about 1,825,876 (215)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Technology development in the country with the revision of engineering courses curriculum
آموزش مهندسی ایران, 2016 Attention to innovation and technology are important factors in increasing a countny,s economic growth and competitiveness. There is no doubt that science and technology are the most basic elements of economic development, and successful countries are ...
firooz bakhtiari nejad , Nahid Sheikhan
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
油脂体的提取方法及其在食品中应用的研究进展Research progress on extraction methods and application in food of oleosomes
Zhongguo youzhi旨在为油脂体的开发利用提供参考，综述了油脂体的结构与组成及提取方法，并介绍了油脂体在食品中的应用现状。油脂体以三酰甘油酯为核心，外层由磷脂-蛋白质膜覆盖，其主要由中性脂质、蛋白质和磷脂组成，此外还含有一些次要生物活性成分。油脂体的提取方法有水剂法、双螺杆压榨法和水酶法，可依据实际情况选择合适的提取方法。油脂体的特定结构以及生物活性成分使其作为天然预乳化水包油乳液具有良好的稳定性和乳化性能，在制备仿乳制品、可食用膜、乳液-凝胶以及作为脂肪替代品和生物活性物质运输载体等方面具有广阔的应用前景 ...
张亚靖1，陈复生1，王颖颖1，刘晨1，郑乾坤1，殷丽君2 (1.College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China; 2.School of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China)
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Desimal, 2018 This study aims to determine the feasibility of mathematical modules with STEM approach and the response of learners and teachers to the attractiveness of the module.
Taza Nur Utami +2 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source