Results 81 to 90 of about 4,404,417 (294)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Understanding the Impact of Different Nucleation Strategies on Bis(2-hydroxyethyl) Terephthalate Crystallization from a Glycolysis Reaction Mixture

Crystals
The recycling of polyethylene terephthalate (PET) is gaining increasing importance, as it enables the conversion of plastic waste into valuable raw materials and contributes to a circular economy.
Lukas Seppelfricke, Henning Loos, Leonard Sander, Louisa-Marie Möller, Kerstin Wohlgemuth   +4 more
doaj   +1 more source

Tensile properties of multi-material interfaces in 3D printed parts

Materials & Design, 2019
Due to continuing progress in multi-material additive manufacturing, the design space for multifunctional and functionally graded materials and structures is significantly increased. To take full advantage of this capability, a solid understanding of the
Thomas S. Lumpe, Jochen Mueller, Kristina Shea   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Elementary Students’ Engineering Design Process Knowledge: Instrument Development and Pilot Test

, 2012
This paper describes the development process of an instrument designed to assess elementary students’ knowledge of the engineering design process. The instrument was adapted from another instrument used with college students and validated through an ...
M. Hsu, M. Cardella, Ș. Purzer
semanticscholar   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Improving Executive Functions Using the Engineering Design Process: A Peer-Mediated Problem-Solving Approach for Autistic Adolescents. [PDF]

Am J Occup Ther, 2023
Murthi K, Patten K.
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Undergraduate Conceptions of the Engineering Design Process: Assessing the Impact of a Human-Centered Design Course

, 2011
Throughout their education, engineering design students not only learn the design process, but also form and refine their conception of engineering design.
L. Oehlberg, A. Agogino
semanticscholar   +1 more source