Results 31 to 40 of about 96,593 (259)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Synergistic Integration of Invasive Alien Species Tradescantia fluminensis Residual Biomass with Commercial Pulp for Enhanced Sustainable Paper Production

Applied Sciences
Invasive alien species pose significant ecological challenges, with Tradescantia fluminensis emerging as a major threat in Europe. This study investigates the potential of repurposing biomass from this invasive plant, collected in Galicia, for use in the
Antía Iglesias, Ángeles Cancela
doaj   +1 more source

KECERDASAN VISUAL SPASIAL DAN KEMANDIRIAN BELAJAR PADA HASIL BELAJAR MATA PELAJARAN GAMBAR TEKNIK DI SMK

Teknologi dan Kejuruan, 2019
Spatial Visual Intelligence and Independence Learning toward the Learning Result on the Subject of Technique Drawing in Vocational High School. Spatial visual intelligence has a significant influence on drawing techniques that are supported by student ...
Muhammad wahyudi, Widiyanti Widiyanti, Didik Nurhadi   +2 more
doaj   +1 more source

Analysis of Chemical Engineering Students’ Needs on Instructional Reading Strategies

Journal of English Education and Teaching, 2023
Reading is an important macro skill besides speaking, writing and listening. Reading is a receptive skill, yet it is still essential for success in both academic and in everyday life.
Sri Diana, Rampeng, Bahar
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of coal drawing law and parameter research in shallow buried double hard and extra-thick coal seam

Gong-kuang zidonghua, 2022
The coal resources in Xinjiang are shallowly buried, the coal seam is thick, resulting in poor top coal caving and drawing. And the roof is overhanging in a large area, which makes it impossible to achieve safe and efficient top coal mining.
SUN Qiang, SHAN Chengfang, LI Yafeng, WANG Jianjian, ZHANG Hao, ZHANG Jiaqi, WU Zhongya   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

PECULIARITIES OF USING THE METHODOLOGY DISTANCE LEARNING OF THE SUBJECT «ENGINEERING AND COMPUTER GRAPHICS» FOR STUDENTS STUDYING BY CORRESPONDENCE

Інформаційні технології і засоби навчання, 2010
A great part of the distance course of the subject «Engineering and Computer Graphics» (ECG) placed in Internet looks as an electronic manual. But the distance training process has a complicated structure and combines not only studying theoretical ...
Olena V. Slobodianiuk
doaj  

A Review of Neural Network Approach on Engineering Drawing Recognition and Future Directions

JOIV: International Journal on Informatics Visualization, 2023
Engineering Drawing (ED) digitization is a crucial aspect of modern industrial processes, enabling efficient data management and facilitating automation. However, the accurate detection and recognition of ED elements pose significant challenges.
Muhammad Syukri Mohd Yazed, Ezak Fadzrin Ahmad Shaubari, Moi Hoon Yap   +2 more
doaj   +1 more source