Results 61 to 70 of about 871,677 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Centering the Marginalized Student’s Voice Through Autoethnography: Implications for Engineering Education Research

open access: yesStudies in Engineering Education, 2020
Background: This autoethnography focuses on the voice of a woman of color in her journey becoming an engineering undergraduate. Purpose: Drawing on critical race theory, this counterstory illustrates structural challenges that some underrepresented ...
Julie P. Martin, Chavone Garza
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Hasil Belajar Permesinan Melalui Praktik Survei Di Sekolah Menegah Kejuruan (SMK) Negeri Di Kota Medan [PDF]

open access: yes, 2010
The purpose of this research is to find out the degree of the relationships between: student's interest in production technic, learning discipline, and the capability in engineering drawing with their learning outcome in machinery practice.
Panjaitan, K. (Keysar)
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Several basic problems in stability evaluation of sliding surface of soil slopes with tension cracks

open access: yesYantu gongcheng xuebao
Focusing on some basic problems in stability evaluation of the sliding surface with tension cracks, the feasibility and adaptability of the two kinds of confusing "ignoring" methods are analyzed through over a thousand examples, and their effects on the ...
LIU Xuejun 1, SONG Fei 2, ZHANG Luyu 3, HOU Xianming 1, HA Yuelong 1
doaj   +1 more source

Specifics of teaching engineering drawing to foreign students of construction degrees

open access: yesMATEC Web of Conferences, 2018
The paper raises a number of questions helping to understand the difficulties in mastering Engineering Graphics by foreign students. It also provides answers to these questions, based on interviews and polls with foreign students studying at the Saint ...
Semenova Natalia
doaj   +1 more source

Solid state sequencer system, phase 2, volume 2. Appendix A - Engineering drawing list Summary report [PDF]

open access: yes
Engineering drawing lists for solid state sequencer system in command module and service module jettison ...

core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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